Circ-SMARCA5 suppresses progression of multiple myeloma by targeting miR-767-5p

BMC Cancer

Table 4 Factors affecting PFS by Cox’s proportional hazards regression analysis

Items	Cox’s regression model
	p value	HR	95%CI
	p value	HR	Lower	Higher
Univariate Cox’s regression
Circ-SMARCA5 (high vs low)	0.006	0.474	0.278	0.806
Age (≥60 years vs < 60 years)	0.390	1.255	0.748	2.106
Gender (male vs female)	0.122	0.663	0.393	1.116
Immunoglobulin subtype
IgG vs others	0.583	0.865	0.516	1.450
IgA vs others	0.423	1.272	0.706	2.290
IgM vs others	0.720	1.436	0.198	10.423
IgD vs others	0.873	0.851	0.117	6.178
Bence-Jones protein vs others	0.847	0.935	0.472	1.850
Hb (≥10 g/dL vs < 10 g/dL)	0.908	0.970	0.578	1.626
Calcium ≥11.5 mg/dL vs < 11.5 mg/dL)	0.749	0.906	0.497	1.655
Scr (≥2 mg/dL vs < 2 mg/dL)	0.005	2.261	1.282	3.990
ALB (≥3.5 mg/dL vs < 3.5 mg/dL)	0.792	1.080	0.612	1.905
β2-MG (≥5.5 mg/L vs < 5.5 mg/L)	< 0.001	22.970	9.519	55.426
LDH (≥220 U/L vs < 220 U/L)	0.480	1.219	0.703	2.113
Durie-Salmon stage (III vs I&II)	0.320	1.302	0.774	2.191
ISS stage (III vs I&II)	< 0.001	22.970	9.519	55.426
Bone lesion (yes vs no)	0.239	0.705	0.393	1.262
Cytogenetics abnormality
t (4; 14) translocation (yes vs no)	0.947	0.972	0.413	2.286
t (14; 16) translocation (yes vs no)	0.589	0.804	0.365	1.773
Del (17p) (yes vs no)	0.453	1.313	0.644	2.676
Multivariate Cox’s regression with Forward Stepwise (Conditional) method
Durie-Salmon stage (III vs I&II)	0.002	2.350	1.363	4.053
ISS stage (III vs I&II)	< 0.001	32.620	12.739	83.528

Factors affecting PFS were determined by univariate and multivariate Cox’s proportional hazards regression analyses, and the multivariate Cox’s proportional hazards regression analysis was performed with Forward Stepwise (Conditional) method. p value < 0.05 was considered significant (in bold)
PFS progression free survival, HR hazard ratio, CI confidence interval, Ig immunoglobulin, Hb hemoglobin, Scr serum creatinine, ALB albumin, β2-MG Beta-2-microglobulin, LDH lactate dehydrogenase, ISS International Staging System

ISSN: 1471-2407