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Table 5 miRNAs regulated by ATRA in pancreatic cancer, glioma, glioblastoma, embryonal carcinoma, and colorectal cancer

From: Modulation of all-trans retinoic acid-induced MiRNA expression in neoplastic cell lines: a systematic review

Study (reference and country) Cell type ATRA treatment miRNAs upregulated miRNAs downregulated
Weiss et al. (2009) [51]
PaTu8988-S and PaTu8988- 1 μmol/L for 72 h miR-10a
Xia et al. (2009) [52]
U343 and U251 1 μmol/L for 48 h miR-125b
Chen et al. [53] (2014) Taiwan U87 MG 10, 20, 40, and 60 μmol/L for 72 h 13; miR-302b, miR-302a, miR-302d, miR-30a, miR-146a, miR-224, miR-135a, miR-137, miR-212, miR-628-3p, miR-200c, miR-146b-5p and miR-136; most significant: miR-302b 15; miR-19a, miR-19b, miR-551b, miR-101, miR-301a, miR-199b-5p, miR-455-5p, miR-565, miR-107, miR-216a, miR-32, miR-33a, miR-17-5p, miR-497 and miR-210; most significant: miR-19a
Chen et al. [54] (2014)
NT2/D1 10 μmol/L for 21 days miR-134
Liu et al. [55] (2018)
HCT116 10, 20, 40, and 60 μmol/L for 24 h miR-3666