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Table 3 miRNAs regulated by ATRA in breast carcinoma cell lines

From: Modulation of all-trans retinoic acid-induced MiRNA expression in neoplastic cell lines: a systematic review

Study (reference and country) Cell type ATRA treatment miRNAs upregulated miRNAs downregulated
Terao et al. (2011) [48] MCF-7 1 μmol/L for 72 h miR-21
Khan et al. (2015) [49]
T47D and SK-BR-3 1 and 5 μmol/L for 24 h miR-10a
Fisher et al. (2015) [50]
SKBR3, MCF-7, MDA-MB-157 10−1 μmol/L (SKBR3) and 1 μmol/L ATRA (MCF-7 and MDA-MB-157) for 36 h 13; mir-1031; miR-1225-5p1, miR-12681, miR-141, miR-188-5p1, miR-19b1, miR-200c1, miR-211, miR-221, miR-513a-5p1, miR-5751, miR-6421 and miR-6641a 17; miR-15b12, miR-9612, miR-20312, miR-18312, miR-210-3p123, miR-362-5p12, miR-14912, miR-125a-5p123, miR-193a-5p12, miR-18512, miR-532-5p12, miR-342-3p12, miR-148a1, miR-3751, miR-193a-3p1, miR-2051 and miR-6601a
  1. 1SKBR3 cell lines; 2MCF-7 cell lines; 3MDA-MB-157 cell lines; aAuthors did not mention the miRNAs most sensitive to ATRA treatment