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Table 2 miRNAs regulated by ATRA in AML cell lines

From: Modulation of all-trans retinoic acid-induced MiRNA expression in neoplastic cell lines: a systematic review

Study (reference and country) Cell type ATRA treatment miRNAs upregulated miRNAs downregulated
Garzon et al. (2007) [23]
United States
NB4 10−1 μmol /L for 4 days 9; miR-15a, miR-15b, miR-16-1, let-7a-3, let-7c, let-7d, miR-223, miR-342, and miR-107; most significant: miR-15b miR-181b
Marchis et al. (2009) [40]
NB4 1 μmol/L for 72 h miR-342
Gao et al. (2011) [41] China U937, HL60, NB4 and leukemic fresh cell lines 1 μmol/L for 72 h 2; miR-15a and miR-16-1; most significant: miR-15a
Lin et al. (2011) [42] China NB4, HL60 and K562 1 μmol/L for 72 h miR-125b
Morris et al. (2013) [43] United States HL60, NB4, PL21, and THP-1 10−3 μmol/L to 1 μmol/L for 21 days miR-150
Zhuang et al. (2014) [44] China NB4 1 μmol/L for 36 h miR-181a
Lin et al. (2015) [45]
HL60 and NB4 3 μmol/L ATRA for 72 h (HL60) and 2 μmol/L ATRA for 4 days (NB4) miR-638
Bräuer-Hartmann et al. (2015) [46] Germany NB4 10−1 μmol/L for 24 h miR-181 cluster (miR-181a, miR-181b, miR-181c and miR-181d); most significant: miR-181a and miR-181b
Yan et al. (2016) [47] United States HL60 10− 1 and 1 μmol/L for 72 h miR-17–92 cluster (miR-17, miR-18a, miR-19b, miR-20a and miR-92); most significant: miR-20a