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Table 1 Characteristics of CIN1- and CIN2+ patients

From: Plasma expression of miRNA-21, − 214, −34a, and -200a in patients with persistent HPV infection and cervical lesions

Area   Total CIN1- CIN2+
n (%) n (%) n (%)
Total   232 (100.00) 92 (39.66) 140 (60.34)
Age <  30 years old 21 (9.05) 9 (3.88) 12 (5.17)
30–49 years old 158 (68.10) 60 (25.86) 98** (42.24)
≥ 50 years old 53 (22.85) 23 (9.91) 30 (12.93)
Passive smoking   85 (36.64) 20 (8.62) 65** (28.02)
No. of pregnancies ≤2 123 (53.02) 55 (23.71) 68 (29.31)
3 54 (23.28) 19 (8.19) 35* (15.09)
≥4 55 (23.71) 18 (7.76) 37** (15.95)
No. of induced abortion ≤2 198 (85.34) 79 (34.05) 119* (51.29)
≥3 34 (14.66) 13 (5.60) 21 (9.05)
Delivery route Cesarean section 43 (18.53) 15 (6.47) 28* (12.07)
Natural birth 158 (68.10) 70 (30.17) 88 (37.93)
Oral contraceptives   79 (34.05) 28 (12.07) 51 (21.98)
Benign tumors   44 (18.97) 18 (7.76) 26 (11.21)
First-degree relatives with cancer   44 (18.97) 13 (5.60) 31** (13.36)
Sexual life First sex ≤20 years old 46 (19.83) 11 (4.74) 35** (15.09)
No. of sexual partners ≥2 63 (27.16) 21 (9.05) 42** (18.10)
  1. In Table 1, 42 normal controls, 31 persistent HPV patients and 19 CIN1 patients were combined to obtain 92 CIN1- subjects; and 54 CIN2, 71 CIN3 and 15 cancer patients were combined for a total of 140 patients in the CIN2+ group
  2. The percentage of patients 30–49 years old with CIN2 was significantly different from that of patients with CIN1, p < 0.01, χ2 = 13.86
  3. The incidence of passive smoking among CIN2+ patients was significantly different from that among CIN1- patients, χ2 = 29.18, p < 0.01
  4. The percentage of CIN2+ patients with three pregnancies was different from that of CIN1- patients, χ2 = 5.37, 0.01 < p < 0.05
  5. The percentage of CIN2+ patients with ≥4 pregnancies was significantly different from that of those who were CIN1-, χ2 = 7.45, p < 0.01
  6. The percentage of CIN2+ patients with ≤2 abortions was significantly different from that of those who were CIN1-, χ2 = 14.09, p < 0.01
  7. The percentage of CIN2+ patients who had a caesarean section was significantly different from that of those who were CIN1-, χ2 = 4.33, 0.01 < p < 0.05
  8. The percentage of patients with a first-degree relative with cancer was significantly different from that of those who were CIN1-, χ2 = 8.14, p < 0.01
  9. The percentage of CIN2+ patients who had their first sexual encounter at ≤20 years was significantly different from that of CIN1- patients, χ2 = 13.91, p < 0.01
  10. The percentage of CIN2+ patients who had ≥2 sexual partners was significantly different from that of CIN1- patients, χ2 = 8.10, p < 0.01