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Table 1 Characteristics of CIN1- and CIN2+ patients

From: Plasma expression of miRNA-21, − 214, −34a, and -200a in patients with persistent HPV infection and cervical lesions

Area

 

Total

CIN1-

CIN2+

n

(%)

n

(%)

n

(%)

Total

 

232

(100.00)

92

(39.66)

140

(60.34)

Age

<  30 years old

21

(9.05)

9

(3.88)

12

(5.17)

30–49 years old

158

(68.10)

60

(25.86)

98**

(42.24)

≥ 50 years old

53

(22.85)

23

(9.91)

30

(12.93)

Passive smoking

 

85

(36.64)

20

(8.62)

65**

(28.02)

No. of pregnancies

≤2

123

(53.02)

55

(23.71)

68

(29.31)

3

54

(23.28)

19

(8.19)

35*

(15.09)

≥4

55

(23.71)

18

(7.76)

37**

(15.95)

No. of induced abortion

≤2

198

(85.34)

79

(34.05)

119*

(51.29)

≥3

34

(14.66)

13

(5.60)

21

(9.05)

Delivery route

Cesarean section

43

(18.53)

15

(6.47)

28*

(12.07)

Natural birth

158

(68.10)

70

(30.17)

88

(37.93)

Oral contraceptives

 

79

(34.05)

28

(12.07)

51

(21.98)

Benign tumors

 

44

(18.97)

18

(7.76)

26

(11.21)

First-degree relatives with cancer

 

44

(18.97)

13

(5.60)

31**

(13.36)

Sexual life

First sex ≤20 years old

46

(19.83)

11

(4.74)

35**

(15.09)

No. of sexual partners ≥2

63

(27.16)

21

(9.05)

42**

(18.10)

  1. In Table 1, 42 normal controls, 31 persistent HPV patients and 19 CIN1 patients were combined to obtain 92 CIN1- subjects; and 54 CIN2, 71 CIN3 and 15 cancer patients were combined for a total of 140 patients in the CIN2+ group
  2. The percentage of patients 30–49 years old with CIN2 was significantly different from that of patients with CIN1, p < 0.01, χ2 = 13.86
  3. The incidence of passive smoking among CIN2+ patients was significantly different from that among CIN1- patients, χ2 = 29.18, p < 0.01
  4. The percentage of CIN2+ patients with three pregnancies was different from that of CIN1- patients, χ2 = 5.37, 0.01 < p < 0.05
  5. The percentage of CIN2+ patients with ≥4 pregnancies was significantly different from that of those who were CIN1-, χ2 = 7.45, p < 0.01
  6. The percentage of CIN2+ patients with ≤2 abortions was significantly different from that of those who were CIN1-, χ2 = 14.09, p < 0.01
  7. The percentage of CIN2+ patients who had a caesarean section was significantly different from that of those who were CIN1-, χ2 = 4.33, 0.01 < p < 0.05
  8. The percentage of patients with a first-degree relative with cancer was significantly different from that of those who were CIN1-, χ2 = 8.14, p < 0.01
  9. The percentage of CIN2+ patients who had their first sexual encounter at ≤20 years was significantly different from that of CIN1- patients, χ2 = 13.91, p < 0.01
  10. The percentage of CIN2+ patients who had ≥2 sexual partners was significantly different from that of CIN1- patients, χ2 = 8.10, p < 0.01
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BMC Cancer

ISSN: 1471-2407

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