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Fig. 1 | BMC Cancer

Fig. 1

From: Clinical correlation of opposing molecular signatures in head and neck squamous cell carcinoma

Fig. 1

Bioinformatics meta-analysis of 8 independent microarray studies on HNSCC tissues samples compared with normal oral tissues. a, Information for the 8 microarray studies: HNSCC anatomical sites, PubMed ID (PMID) referenced to published paper, microarray data archive (GEO or *Oncomine), number of patients’ tumour, normal and lymph-node metastastic (LNM) samples were as indicated. b, Based on statistical ranking of the most differentially expressed genes, top 10 upregulated and top 10 downregulated across the 8 studies were shortlisted for further validation on cell lines. c, Relative gene expression mRNA levels (Log2 Ratio) were measured using RT-qPCR and compared in a panel of 8 primary normal human oral keratinocytes (OK355, HOKG, OK113, NOK, NOK1, NOK3, NOK16 and NOK376) and 10 HNSCC cell lines (SCC4, SCC9, SCC15, SCC25, SqCC/Y1, UK1, VB6, CaLH2, CaDec12 and 5PT). We identified 3 most significantly upregulated (PLAU, FN1 and CDCA5) and 3 most significantly downregulated (CRNN, CLEC3B and DUOX1) in HNSCC cell lines and their gene putative functions (from NCBI’s Gene database) are listed in D

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