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Table 2 Cases of vaginal clear cell carcinoma due to the potential malignant transformation of vaginal adenosis or atypical vaginal adenosis without prenatal DES exposure in the English literature

From: Malignant transformation of vaginal adenosis to clear cell carcinoma without prenatal diethylstilbestrol exposure: a case report and literature review

Reference Age at diagnosis of carcinoma Atypical adenosis Congenital anomalies Courses from adenosis to carcinoma Treatment Disease-free survival Overall survival Recurrence Mortality
Uehara T et al. [5] 54 years None Bicornuate uterus and vaginal septum and left ureteral agenesis 3 months Anterior pelvic exenteration 43 months 43 months No No
Satou Y et al. [6] 38 years None Didelphys uterus, duplicated and imperforated vagina Not available Radical hysterectomy and chemotherapy Not available 16 months Not available Yes
Prasad CJ [7] 34 years Yes None Not available Vaginectomy with bilateral inguinal lymph node dissection, chemotherapy of cisplatin and etoposide, teletherapy, brachytherapy Not available 6 months With tumor noted at deep margins of the vagina Yes
Case in the report 45 years Yes None 6 years Hysterectomy, wide local resection of vaginal lesion, and brachytherapy 16 months 16 months No No