Table 2 Cases of vaginal clear cell carcinoma due to the potential malignant transformation of vaginal adenosis or atypical vaginal adenosis without prenatal DES exposure in the English literature
Reference | Age at diagnosis of carcinoma | Atypical adenosis | Congenital anomalies | Courses from adenosis to carcinoma | Treatment | Disease-free survival | Overall survival | Recurrence | Mortality |
|---|---|---|---|---|---|---|---|---|---|
Uehara T et al. [5] | 54 years | None | Bicornuate uterus and vaginal septum and left ureteral agenesis | 3 months | Anterior pelvic exenteration | 43 months | 43 months | No | No |
Satou Y et al. [6] | 38 years | None | Didelphys uterus, duplicated and imperforated vagina | Not available | Radical hysterectomy and chemotherapy | Not available | 16 months | Not available | Yes |
Prasad CJ [7] | 34 years | Yes | None | Not available | Vaginectomy with bilateral inguinal lymph node dissection, chemotherapy of cisplatin and etoposide, teletherapy, brachytherapy | Not available | 6 months | With tumor noted at deep margins of the vagina | Yes |
Case in the report | 45 years | Yes | None | 6 years | Hysterectomy, wide local resection of vaginal lesion, and brachytherapy | 16 months | 16 months | No | No |