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Table 1 Clinicopathological characteristics of patients with or without UFUR maintenance after adjuvant chemotherapy for ypstage III rectal cancer

From: Monthly tegafur–uracil maintenance for increasing relapse-free survival in ypStage III rectal cancer patients after preoperative radiotherapy, radical resection, and 12 postoperative chemotherapy cycles: a retrospective study

Variable Category Patient number (%) of each category in variable Patients with UFUR maintenance
Patient number (%) in each category P value
Age group
  < 65 years 45 (44.1) 26 (57.8) 0.488
  ≥ 65 years 57 (55.9) 29 (50.9)  
Sex
 Female 43 (42.2) 24 (55.8) 0.743
 Male 59 (57.8) 31 (52.5)  
Tumor location
  < 6 cm 46 (45.1) 27 (58.7) 0.381
  ≥ 6 cm 56 (54.9) 28 (50.0)  
Serum CEA
  ≥ 5 ng/mL 45 (44.1) 26 (57.8) 0.548
  < 5 ng/mL 57 (55.9) 29 (50.9)  
Type of surgery
 LAR 77 (75.5) 42 (76.3) 0.215
 APR 3 (2.9) 3 (5.5)  
 Hartmann 1 (1.0) 1 (1.8)  
 ISR 21 (20.6) 9 (16.4)  
Complication of surgery, Clavien-Dindo
 0 84 (82.4) 47 (85.5) 0.494
 1 4 (3.9) 1 (1.8)  
 2 6 (5.9) 2 (3.6)  
 3 7 (6.9) 4 (7.3)  
 4 1 (0.9) 1 (1.8)  
ypTNM stage
 IIIa 9 (8.8) 7 (77.8) 0.313
 IIIb 65 (63.7) 33 (50.8)  
 IIIc 28 (27.5) 15 (53.6)  
ypTNM, T stage
 T2 14 (13.7) 10 (71.4) 0.198
 T3 66 (64.7) 36 (54.5)  
 T4 22 (21.6) 9 (40.9)  
ypTNM, N stage
 N1 60 (58.8) 33 (55.0) 0.794
 N2 42 (41.2) 22 (52.4)  
Histologic type
 Adenocarcinoma 90 (88.2) 48 (53.3) 0.872
 Signet ring cell 8 (7.8) 5 (62.5)  
 Mucinous 4 (3.9) 2 (50.0)  
Histologic grade
 Well/ Moderate 70 (68.6) 37 (52.9) 0.750
 Poorly 32 (31.4) 18 (56.3)  
Number of ELN
  ≥ 12 79 (77.5) 42 (53.2) 0.776
  < 12 23 (22.5) 13 (56.5)  
Metastatic LNR
  ≥ 0.3 40 (39.2) 19 (47.5) 0.296
  < 0.3 62 (60.8) 36 (58.1)  
Regimen of Adjuvant Chemotherapy
 5FU/LV 51 (50) 24 (47.1) 0.164
 FOLFOX 51 (50) 31 (60.8)  
ECOG (before treatment)
 0 32 (31.4) 17 (53.1) 0.362
 1 63 (61.8) 32 (50.8)  
 2 6 (5.9) 6 (100)  
  1. UFUR tegafur-uracil, CEA carcinoembryonic antigen, LAR lower anterior resection, APR combined abdominal-perineal resection, ISR intersphincteric resection, ELN total examined nodes number, LNR the ratio of metastatic lymph nodes to the total examined nodes number
  2. The Clavien-Dindo Classification: https://www.assessurgery.com/clavien-dindo-classification/