Fig. 4

Spheroid cells demonstrate increased drug resistance. (a) H727 and H720 PA and 3rd generation SP cells were treated with increasing doubling doses in a range (0-16 μM) of cisplatin as shown and cytotoxicity assayed with AlamarBlue. Percentage cell viability was measured. b&c IC50 values were calculated for the response of H727 and H720 PA versus SP to cisplatin and presented in Tables