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Fig. 6 | BMC Cancer

Fig. 6

From: Reduction of metastatic potential by inhibiting EGFR/Akt/p38/ERK signaling pathway and epithelial-mesenchymal transition after carbon ion exposure is potentiated by PARP-1 inhibition in non-small-cell lung cancer

Fig. 6

The cartoon picture represents the mechanisms of inhibition of in-vitro metastatic potential after single and combined treatment. The downward or upward arrows with three different colours beside the protein represent down-regulation or up-regulation respectively of that protein for only PARP-1 inhibition (red), only 12C ion exposure (green) and combined treatment (blue). Phosphorylation of each protein is denoted by P within oval shape attached with the respective protein. The down arrow of different colours beside P denotes reduction of phosphorylation of the respective proteins after different treatments

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