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Fig. 4 | BMC Cancer

Fig. 4

From: Oct4 upregulates osteopontin via Egr1 and is associated with poor outcome in human lung cancer

Fig. 4

Oct4-overexpressing lung tumors express higher levels of Egr1 in a mouse tumor model, and knockdown of Oct4 reduces the migratory capability of lung cancer cells. a, Immunohistochemical staining for Oct4, Egr1 and OPN in the tumors excised at day 60 from NOD/SCID mice that had been inoculated with 5 × 106 of A549-Oct4 cells via the tail vein. b, Lung tissues of tumor-bearing mice were harvested, and the number of metastatic nodules was counted. Data are mean ± SEM. *, p < 0.05; **, p < 0.01

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