Table 5 Adjusted odds ratios for FN in cycle 1, cycle 2, cycles 3+, last cycle, and all cycles, respectively (Narrow Definition of FN)
| Â | Adjusted Odds Ratio for FN (95% CI, p-value)* | ||||
|---|---|---|---|---|---|
Cycle 1 | Cycle 2 | Cycles ≥3 | Last Cycle | All Cycles | |
Commercial | |||||
 Independent Variables | |||||
  No PEG Prophylaxis | 4.2 (3.8–4.7, < 0.001) | 4.1 (3.3–4.9, < 0.001) | 3.3 (2.9–3.8, < 0.001) | 3.2 (2.7–3.8, < 0.001) | 4.2 (3.9–4.5, < 0.001) |
  FN in Prior Cycle | – | 5.1 (3.7–7.0, < 0.001) | 5.9 (4.9–7.0, < 0.001) | 3.9 (3.0–5.0, < 0.001) | 3.1 (2.6–3.5, < 0.001) |
  Regimen | |||||
   TAC | 4.4 (3.8–5.1, < 0.001) | 2.2 (1.6–3.2, < 0.001) | 3.0 (2.4–3.8, < 0.001) | 2.7 (2.0–3.6, < 0.001) | 4.1 (3.3–5.2, < 0.001) |
   TC | – | – | – | – | – |
   TCH | 1.0 (0.9–1.1, 0.963) | 1.4 (1.1–1.8, 0.009) | 1.2 (1.0–1.4, 0.130) | 1.2 (0.9–1.5, 0.191) | 1.3 (1.0–1.6, 0.040) |
   CHOP±R | 1.4 (1.2–1.6, < 0.001) | 2.0 (1.5–2.7, < 0.001) | 3.5 (2.9–4.4, < 0.001) | 1.7 (1.4–2.1, < 0.001) | 3.0 (2.0–4.5, < 0.001) |
  Age | |||||
   18–49 | – | – | – | – | – |
   50–64 | 1.1 (1.0–1.2, 0.216) | 1.1 (0.9–1.4, 0.332) | 1.0 (0.9–1.2, 0.671) | 1.3 (1.1–1.6, 0.010) | 1.1 (1.0–1.2, 0.207) |
   65–74 | 1.5 (1.3–1.8, < 0.001) | 1.2 (0.8–1.6, 0.354) | 1.4 (1.1–1.8, 0.002) | 1.6 (1.2–2.1, 0.003) | 1.4 (1.3–1.6, < 0.001) |
   ≥ 75 | 2.1 (1.7–2.7, < 0.001) | 1.7 (1.1–2.6, 0.012) | 2.0 (1.5–2.6, < 0.001) | 4.0 (2.9–5.5, < 0.001) | 2.1 (1.7–2.4, < 0.001) |
Medicare | |||||
 Independent Variables | |||||
  No PEG Prophylaxis | 2.0 (1.9–2.2, < 0.001) | 2.2 (2.0–2.5, < 0.001) | 1.6 (1.5–1.8, < 0.001) | 1.3 (1.2–1.4, < 0.001) | 1.9 (1.8–2.0, < 0.001) |
  FN in Prior Cycle | – | 4.6 (4.0–5.3, < 0.001) | 4.1 (3.8–4.4, < 0.001) | 2.4 (2.1–2.6, < 0.001) | 2.7 (2.5–2.9, < 0.001) |
  Regimen | |||||
   TAC | 3.1 (2.7–3.7, < 0.001) | 2.5 (1.9–3.5, < 0.001) | 2.8 (2.3–3.5, < 0.001) | 2.5 (2.0–3.1, < 0.001) | 2.7 (2.4–3.0, < 0.001) |
   TC | – | – | – | – | – |
   TCH | 0.6 (0.6–0.7, < 0.001) | 0.7 (0.5–0.9, 0.001) | 0.6 (0.5–0.8, < 0.001) | 0.7 (0.6–0.8, < 0.001) | 0.6 (0.5–0.6, < 0.001) |
  CHOP±R | 1.6 (1.5–1.7, < 0.001) | 2.1 (1.9–2.5, < 0.001) | 2.9 (2.6–3.2, < 0.001) | 2.1 (1.9–2.3, < 0.001) | 1.9 (1.8–2.0, < 0.001) |
  Age | |||||
  65–74 | – | – | – | – | – |
   75–84 | 1.2 (1.1–1.3, < 0.001) | 1.0 (0.8–1.1, 0.759) | 1.1 (1.0–1.2, 0.011) | 1.2 (1.1–1.4, < 0.001) | 1.1 (1.1–1.2, < 0.001) |
   ≥ 85 | 1.4 (1.3–1.6, < 0.001) | 1.1 (1.0–1.3, 0.047) | 1.2 (1.1–1.4, < 0.001) | 1.6 (1.5–1.8, < 0.001) | 1.3 (1.3–1.4, < 0.001) |