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Table 1 Demographic and Treatment Characteristics of the Participants

From: Effects of adjunct testosterone on cardiac morphology and function in advanced cancers: an ancillary analysis of a randomized controlled trial

Characteristic All Patients
(n = 16)
Placebo
(n = 10)
Testosterone
(n = 6)
P = value
Time (mos) from diagnosis to enrollment – mean (SD) 3.1 (3.2) 2.9 (3.4) 3.6 (3.1) 0.684
Age (yrs) – mean (SD) 50.9 (9.5) 48.4 (10.9) 55.0 (5.1) 0.189
BMI (kg/m2) – mean (SD) 22.1 (6.8) 23.9 (7.3) 19.3 (5.2) 0.200
aExercise behavior (activity score) – mean (SD) 9.0 (8.0) 9.9 (9.6) 7.1 (3.6) 0.588
Race – no. (%)     0.330
 Non-Hispanic white 11 (69) 6 (60) 5 (83)  
 Other group 5 (31) 4 (40) 1 (20)  
Sex – no. (%)     0.091
 Male 7 (44) 6 (60) 1 (17)  
 Female 9 (56) 4 (40) 5 (83)  
Smoking – no. (%) n = 16 n = 10 n = 6 0.355
 Never 4 (25) 3 (30) 1 (17)  
 Former 7 (44) 3 (330) 4 (67)  
 Current 5 (31) 4 (40) 1 (17)  
Disease stage – no. (%) n = 15 n = 9 n = 6 0.852
 IIB 1 (7) 0 (0) 1 (17)  
 III 0 (0) 0 (0) 0 (0)  
 IIIB 4 (27) 3 (33) 1 (17)  
 IV 0 (0) 0 (0) 0 (0)  
 IVA 8 (53) 5 (56) 3 (50)  
 IVB 2 (13) 1 (11) 1 (17)  
Cancer Type – no. (%)     1.000
 Cervical 6 (38) 4 (40) 2 (33)  
 Head/neck 10 (62) 6 (60) 4 (37)  
PEG feeding tube – no. (%) 6 (38) 3 (30) 3 (50) 0.986
Current Therapy – no. (%)
 Chemotherapy 11 (69) 6 (60) 5 (83) 0.985
 Radiotherapy 13 (81) 9 (90) 4 (67)  
 Other Therapy 0 (0) 0 (0) 0 (0)  
Prior therapy – no. (%) n = 16 n = 10 n = 6 0.927
 Surgery 2 (13) 2 (20) 0 (0)  
 Chemotherapy 0 (0) 0 (0) 0 (0)  
 Radiotherapy 0 (0) 0 (0) 0 (0)  
 Other Therapy 0 (0) 0 (0) 0 (0)  
Current Medications – no. (%) n = 16 n = 10 n = 6 0.728
 Beta-blocker 0 (0) 0 (0) 0 (0)  
 ACE inhibitor 1 (6) 1 (10) 0 (0)  
 ARB 1 (6) 1 (10) 0 (0)  
 Diuretic 1 (6) 1 (10) 0 (0)  
 Calcium channel blocker 1 (6) 1 (10) 0 (0)  
 Aspirin 3 (19) 2 (20) 1 (17)  
 Statin 2 (13) 2 (20) 0 (0)  
Pre-existing conditions – no. (%) n = 16 n = 10 n = 6 0.586
 Peripheral vascular disease 2 (13) 1 (10) 1 (17)  
 Coronary artery disease 1 (6) 1 (10) 0 (0)  
 Osteoporosis 1 (6) 0 (0) 1 (17)  
 Arrhythmia 0 (0) 0 (0) 0 (0)  
 Arthritis 0 (0) 0 (0) 0 (0)  
 Type II diabetes 2 (13) 2 (20) 0 (0)  
 Hyperlipidemia 2 (13) 2 (20) 0 (0)  
 Hypertension 1 (6) 1 (10) 0 (0)  
  1. Abbreviations: SD standard deviation, BMI body mass index, ACE angiotensin converting enzyme, ARB angiotensin II receptor blockers. aExercise behavior sum of mild, moderate, and strenuous exercise obtained from ActiGraph 3 axis accelerometry monitors available in a subset of patients (n = 8 placebo; n = 4 testosterone). No significant differences between the groups. P-values provided are from t-tests when group means were compared or chi-square tests when comparing frequency of cases between the groups