Combination therapy of brain radiotherapy and EGFR-TKIs is more effective than TKIs alone for EGFR-mutant lung adenocarcinoma patients with asymptomatic brain metastasis

Table 3 Multivariate analysis of prognostic factors for iPFS in 78 patients

	P	HR	95.0% CI for HR
	P	HR	Lower	Upper
Gender (male vs. female)	0.137	0.16	0.02	1.78
Age (<65y vs. ≥65y)	0.890	0.94	0.37	2.34
Smoking history (never vs. smoking)	0.134	5.57	0.59	52.53
EGFR mutation (L858r vs. Del19 vs. rare mutations)	0.665	0.83	0.36	1.91
BM No. (≤3 vs.>3)	0.315	0.63	0.26	1.55
Metastases(B vs. B + E)	0.740	0.82	0.26	2.58
Intracranial symptom (have vs. No)	0.267	0.60	0.24	1.48
First-line treatment (Yes vs. No)	0.445	1.55	0.51	4.74
KPS score (<80% vs ≥80%)	0.918	0.94	0.26	3.37

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