BMC Cancer

Table 1 Clinical and Molecular Characteristics of Included Patients

From: Combination therapy of brain radiotherapy and EGFR-TKIs is more effective than TKIs alone for EGFR-mutant lung adenocarcinoma patients with asymptomatic brain metastasis

	TKI alone		TKI + RT
Characteristic	(n = 29)	%	(n = 49)	%	p Value
Age (years)					0.639
Median	59		59
Range	32–74		35–83
< 65	21	72.4	33	67.3
≥65	8	27.6	16	32.7
Gender					0.729
Male	13	44.8	20	40.8
Female	16	55.2	29	59.2
Smoking history					0.729
Never or light	16	55.2	29	59.2
Heavy	13	44.8	20	40.8
EGFR mutation					0.323
Del19	9	31.0	22	44.9
L858r	18	62.0	26	53.1
Other	2	7.0	1	2.0
BM no. at time of diagnosis					0.292
≤3	16	55.2	21	42.9
>3	13	44.8	28	57.1
Extracranial metastases					0.454
Yes	24	82.8	37	75.5
No	5	17.2	12	24.5
Intracranial Symptoms					0.012
Without	22	75.9	23	46.9
With	7	24.1	26	53.1
Lung-mol GPA classification					0.339
0–1	1	3.5	2	4.1
1.5–2	9	31.0	12	24.5
2.5–3	12	41.4	22	44.9
3.5–4	7	24.1	13	26.5
Primary tumor location					0.128
Left Lung	17	58.6	20	40.8
Right Lung	12	41.4	29	59.2
KPS score(%)					0.801
<80	6	20.7	9	18.4
≥80	23	79.3	40	81.6

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ISSN: 1471-2407

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