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Table 2 Baseline and dynamic serum ALP with the OS of PDAC patients by curative resection

From: Dynamic serum alkaline phosphatase is an indicator of overall survival in pancreatic cancer

Covariates Cox proportional hazards model AG model
Crude HR (95% CI) Adjusted HR (95% CI) Crude HR (95% CI) Adjusted HR (95% CI)
Resected Sex (Male) 1.17 (0.66, 2.06)   1.23 (0.71, 2.13)  
PDAC Age (+ 5 years) 1.30 (1.11, 1.53)** 1.30 (1.11, 1.53)** 1.29 (1.13, 1.48)** 1.17 (0.95, 1.45)
Chemotherapy (Yes) 0.80 (0.44, 1.43)   0.89 (0.52, 1.52)  
Serum ALP (+ 20 U/L) 1.02 (0.97, 1.07)   1.09 (1.07, 1.11)** 1.09 (0.92, 1.29)
Serum ALB (+ 5 g/L) 1.08 (0.82, 1.41)   0.52 (0.41, 0.65)** 0.66 (0.51, 0.87)
Serum TBIL (+ 5 μmol/L) 1.01 (1.00, 1.03)   1.03 (1.01, 1.05)** 0.99 (0.96, 1.01)
Leukocyte count (+ 1 109/L) 0.98 (0.91, 1.04)   1.08 (1.04, 1.13)** 1.06 (1.02, 1.11)
Serum ALP × Age   1.00 (0.99, 1.01)
Un-resected Sex (Male) 0.92 (0.66, 1.28)   0.93 (0.76, 1.14)  
PDAC Age (+ 5 years) 1.12 (1.03, 1.21)** 1.07 (0.99, 1.16) 1.09 (1.03, 1.14)** 1.11 (0.89, 1.37)
Chemotherapy (Yes) 0.71 (0.51, 0.98)** 0.97 (0.65, 1.44) 0.69 (0.56, 0.84)** 1.52 (0.68, 3.40)
Serum ALP (+ 20 U/L) 1.01 (1.00, 1.02)   1.03 (1.02, 1.03)** 0.99 (0.81, 1.22)
Serum ALB (+ 5 g/L) 0.73 (0.64, 0.83)** 0.78 (0.66, 0.92)** 0.51 (0.46, 0.56)** 0.64 (0.48, 0.86)
Serum TBIL (+ 5 μmol/L) 1.01 (1.00, 1.01)* 1.00 (0.99, 1.01) 1.03 (1.02, 1.03)** 0.98 (0.96, 1.01)
Leukocyte count (+ 1 109/L) 1.09 (1.03, 1.16)** 1.07 (1.01, 1.14)** 1.04 (1.02, 1.06)** 1.07 (1.02, 1.11)**
Serum ALP × Age 1.01 (0.99, 1.02)
Serum ALP × Chemotherapy 0.96 (0.91, 1.00)
  1. * p < 0.1 ** p < 0.05