Table 2 Baseline and dynamic serum ALP with the OS of PDAC patients by curative resection
From: Dynamic serum alkaline phosphatase is an indicator of overall survival in pancreatic cancer
Covariates | Cox proportional hazards model | AG model | |||
|---|---|---|---|---|---|
Crude HR (95% CI) | Adjusted HR (95% CI) | Crude HR (95% CI) | Adjusted HR (95% CI) | ||
Resected | Sex (Male) | 1.17 (0.66, 2.06) | 1.23 (0.71, 2.13) | ||
PDAC | Age (+ 5 years) | 1.30 (1.11, 1.53)** | 1.30 (1.11, 1.53)** | 1.29 (1.13, 1.48)** | 1.17 (0.95, 1.45) |
Chemotherapy (Yes) | 0.80 (0.44, 1.43) | 0.89 (0.52, 1.52) | |||
Serum ALP (+ 20 U/L) | 1.02 (0.97, 1.07) | 1.09 (1.07, 1.11)** | 1.09 (0.92, 1.29) | ||
Serum ALB (+ 5 g/L) | 1.08 (0.82, 1.41) | 0.52 (0.41, 0.65)** | 0.66 (0.51, 0.87) | ||
Serum TBIL (+ 5 μmol/L) | 1.01 (1.00, 1.03) | 1.03 (1.01, 1.05)** | 0.99 (0.96, 1.01) | ||
Leukocyte count (+ 1 109/L) | 0.98 (0.91, 1.04) | 1.08 (1.04, 1.13)** | 1.06 (1.02, 1.11) | ||
Serum ALP × Age | – | – | 1.00 (0.99, 1.01) | ||
Un-resected | Sex (Male) | 0.92 (0.66, 1.28) | 0.93 (0.76, 1.14) | ||
PDAC | Age (+ 5 years) | 1.12 (1.03, 1.21)** | 1.07 (0.99, 1.16) | 1.09 (1.03, 1.14)** | 1.11 (0.89, 1.37) |
Chemotherapy (Yes) | 0.71 (0.51, 0.98)** | 0.97 (0.65, 1.44) | 0.69 (0.56, 0.84)** | 1.52 (0.68, 3.40) | |
Serum ALP (+ 20 U/L) | 1.01 (1.00, 1.02) | 1.03 (1.02, 1.03)** | 0.99 (0.81, 1.22) | ||
Serum ALB (+ 5 g/L) | 0.73 (0.64, 0.83)** | 0.78 (0.66, 0.92)** | 0.51 (0.46, 0.56)** | 0.64 (0.48, 0.86) | |
Serum TBIL (+ 5 μmol/L) | 1.01 (1.00, 1.01)* | 1.00 (0.99, 1.01) | 1.03 (1.02, 1.03)** | 0.98 (0.96, 1.01) | |
Leukocyte count (+ 1 109/L) | 1.09 (1.03, 1.16)** | 1.07 (1.01, 1.14)** | 1.04 (1.02, 1.06)** | 1.07 (1.02, 1.11)** | |
Serum ALP × Age | – | – | – | 1.01 (0.99, 1.02) | |
Serum ALP × Chemotherapy | – | – | – | 0.96 (0.91, 1.00) | |