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Fig. 4 | BMC Cancer

Fig. 4

From: Targeted genomic profiling identifies frequent deleterious mutations in FAT4 and TP53 genes in HBV-associated hepatocellular carcinoma

Fig. 4

Effects of FAT4 silencing on liver cancer cell growth and proliferation. (a) Confirmation on the efficiency of FAT4 silencing by assessing the mRNA and protein expression levels after siRNA transfection at 24 h and 48 h, respectively. (b) siRNA knockdown of FAT4 significantly increased cell proliferation compared with cells transfected with control siRNA at 48 and 72 h. (c) Significantly increased in cell growth was observed in cells transfected with FAT4 siRNA at 48 and 72 h after transfection. (d) Representative morphological appearance of SNU-387 cells treated with FAT4 siRNA by phase contrast microscopy at 24, 48, 72 h (40× magnification). Arrows indicate rapidly proliferating cell clumps. Data are mean values ± SEM of triplicate determinations (*P < 0.01 and ***P < 0.0001)

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