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Table 4 Potential effect modifiers of multivariable adjusteda HR and 95% CI for risk of breast cancer-specific mortality associated with wine consumption from age 15 years until breast cancer diagnosis

From: Pre-diagnosis alcohol consumption and mortality risk among black women and white women with invasive breast cancer

 

Wine consumption from age 15 years until breast cancer diagnosis, average drinks/week

Non-drinkers

< 1

1–< 3

≥3

P trend

P heterogeneity

Household income, times the federal poverty guideline

  < 3

No. Death

148

67

27

6

  

HR (95% CI)

Referent

0.94 (0.69–1.28)

0.70 (0.46–1.07)

0.32 (0.14–0.74)

0.003

0.005

  ≥ 3

No. Death

226

117

50

29

  

HR (95% CI)

Referent

0.96 (0.74–1.23)

0.82 (0.59–1.14)

1.09 (0.72–1.63)

0.98

 

Race

 Black

No. Death

215

75

26

9

  

HR (95% CI)

Referent

1.06 (0.79–1.41)

0.64 (0.42–0.98)

0.65 (0.33–1.30)

0.05

0.23

 White

No. Death

167

116

54

26

  

HR (95% CI)

Referent

0.92 (0.71–1.19)

0.88 (0.64–1.22)

0.82 (0.53–1.26)

0.33

 

Education

  ≤ High school

No. Death

185

59

27

13

  

HR (95% CI)

Referent

0.82 (0.60–1.12)

0.88 (0.58–1.35)

1.09 (0.61–1.96)

0.93

0.11

  > High school

No. Death

197

132

53

22

  

HR (95% CI)

Referent

1.03 (0.80–1.31)

0.73 (0.52–1.00)

0.64 (0.40–1.00)

0.02

 

Menopausal status at diagnosis

 Pre-MP

No. Death

177

109

49

19

  

HR (95% CI)

Referent

0.95 (0.73–1.24)

0.95 (0.68–1.34)

0.73 (0.44–1.19)

0.24

0.42

 Post-MP

No. Death

166

61

21

11

  

HR (95% CI)

Referent

0.93 (0.68–1.28)

0.68 (0.43–1.09)

0.63 (0.34–1.19)

0.07

 

BMI 5-years before diagnosis (kg/m2)

  < 25

No. Death

154

113

53

23

  

HR (95% CI)

Referent

0.97 (0.75–1.25)

0.79 (0.57–1.10)

0.78 (0.49–1.22)

0.15

0.80

  ≥ 25

No. Death

228

78

27

12

  

HR (95% CI)

Referent

0.96 (0.72–1.27)

0.75 (0.49–1.14)

0.73 (0.40–1.33)

0.17

 

Comorbid conditionb

 No

No. Death

206

125

53

27

  

HR (95% CI)

Referent

0.92 (0.72–1.18)

0.80 (0.58–1.11)

0.74 (0.48–1.12)

0.10

0.96

 Yes

No. Death

176

66

27

8

  

HR (95% CI)

Referent

1.04 (0.77–1.41)

0.74 (0.49–1.13)

0.84 (0.41–1.75)

0.30

 

Cigarette smoking

 Never

No. Death

227

84

30

10

  

HR (95% CI)

Referent

1.06 (0.79–1.41)

1.00 (0.66–1.51)

0.69 (0.36–1.33)

0.34

0.77

 Ever

No. Death

155

107

50

25

  

HR (95% CI)

Referent

0.91 (0.70–1.17)

0.68 (0.49–0.94)

0.79 (0.51–1.22)

0.08

 

Stage of breast cancer at diagnosis

 Localized

No. Death

100

55

27

11

  

HR (95% CI)

Referent

1.10 (0.78–1.54)

1.06 (0.69–1.65)

0.80 (0.42–1.51)

0.60

0.43

 Non-localized

No. Death

282

136

53

24

  

HR (95% CI)

Referent

0.92 (0.73–1.16)

0.69 (0.50–0.94)

0.76 (0.49–1.17)

0.05

 

Estrogen receptor status

 Positive

No. Death

161

82

40

20

  

HR (95% CI)

Referent

0.93 (0.70–1.24)

0.80 (0.55–1.16)

0.87 (0.53–1.41)

0.35

0.80

 Negative

No. Death

160

93

35

13

  

HR (95% CI)

Referent

1.11 (0.84–1.49)

0.87 (0.59–1.29)

0.76 (0.43–1.37)

0.25

 

Histogologic type

 Ductal

No. Death

286

150

62

24

  

HR (95% CI)

Referent

0.97 (0.77–1.22)

0.74 (0.54–1.00)

0.66 (0.43–1.03)

0.02

0.33

 Lobular

No. Death

37

25

6

8

  

HR (95% CI)

Referent

1.17 (0.72–1.93)

0.50 (0.21–1.19)

1.21 (0.56–2.61)

0.91

 
  1. Abbreviations: HR hazard ratio, CI confidence interval, MP menopausal
  2. aAll models are stratified by age at diagnosis, and include study site, race, education, household income, number of mammograms within the 5 years before breast cancer diagnosis, body mass index 5-years before diagnosis, number of comorbidities before breast cancer diagnosis, smoking history, stage, estrogen receptor status, histologic type of breast cancer tumor, beer consumption, and liquor consumption
  3. bComorbidities included hypertension, myocardial infarction, stroke, diabetes, and cancers other than non-melanoma skin cancers
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BMC Cancer

ISSN: 1471-2407

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