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Table 2 Multivariable adjusteda HR and 95% CI for mortality risk associated with alcohol consumption before breast cancer diagnosis

From: Pre-diagnosis alcohol consumption and mortality risk among black women and white women with invasive breast cancer

  Person-years Breast cancer-specific mortality Mortality due to causes other than breast cancer All-cause mortality
No.
Death
HR (95% CI) No.
Death
HR (95% CI)  No.
Death
HR (95% CI)
Alcohol drinking status prior to breast cancer diagnosis
 Non-drinkers 14,468 382 Referent 87 Referent 469 Referent
 Drinkers 22,684 442 0.87 (0.75–1.01) 144 1.17 (0.87–1.56) 586 0.93 (0.81–1.06)
Average alcohol consumption from age 15 years until breast cancer diagnosis (drinks/week)
 Non-drinkers 14,468 382 Referent 87 Referent 469 Referent
  < 1 6555 140 1.04 (0.85–1.27) 34 1.21 (0.80–1.84) 174 1.07 (0.90–1.28)
 1–< 3 7485 139 0.82 (0.67–1.01) 45 1.28 (0.87–1.87) 184 0.90 (0.76–1.08)
 3–< 7 5490 106 0.80 (0.64–1.01) 41 1.17 (0.79–1.74) 147 0.88 (0.72–1.07)
  ≥ 7 3153 57 0.75 (0.56–1.00) 24 0.95 (0.59–1.54) 81 0.79 (0.62–1.01)
Ptrend    0.01   0.73   0.03
Average alcohol consumption in recent 5-year period beginning 7 years before breast cancer diagnosis and continuing until 2 years before breast cancer diagnosis (drinks/week)
 Non-drinkers 14,468 382 Referent 87 Referent 469 Referent
  < 1 4385 85 0.88 (0.69–1.12) 24 1.27 (0.80–2.04) 109 0.94 (0.76–1.17)
 1–< 3 4835 82 0.83 (0.65–1.07) 27 1.28 (0.82–2.02) 109 0.91 (0.74–1.13)
 3–< 7 4464 91 0.87 (0.68–1.10) 24 1.02 (0.63–1.63) 115 0.90 (0.73–1.11)
  ≥ 7 4614 78 0.74 (0.57–0.95) 27 0.89 (0.56–1.40) 105 0.77 (0.62–0.97)
Ptrend    0.04   0.50   0.05
 Drank alcohol, but not in this period 4386 106 1.01 (0.81–1.26) 42 1.37 (0.92–2.02) 148 1.08 (0.89–1.31)
Average alcohol consumption in recent 2-year period beginning 2 years before breast cancer diagnosis until breast cancer diagnosis (drinks/week)
 Non-drinkers 14,468 382 Referent 87 Referent 469 Referent
  < 1 3863 67 0.76 (0.58–1.00) 19 1.21 (0.72–2.02) 86 0.84 (0.66–1.06)
 1–< 3 4560 79 0.82 (0.64–1.06) 30 1.53 (0.99–2.36) 109 0.94 (0.76–1.17)
 3–< 7 4000 79 0.86 (0.67–1.11) 19 0.90 (0.54–1.52) 98 0.87 (0.69–1.09)
  ≥ 7 4418 74 0.73 (0.56–0.95) 27 0.97 (0.61–1.54) 101 0.79 (0.63–0.99)
Ptrend    0.08   0.60   0.12
 Drank alcohol, but not in this period 5842 143 1.06 (0.87–1.30) 49 1.21 (0.84–1.76) 192 1.09 (0.91–1.30)
  1. Abbreviations: HR hazard ratio, CI confidence interval
  2. aAll models are stratified by age at diagnosis, and include study site, race, education, household income, number of mammograms within the 5 years before breast cancer diagnosis, body mass index 5-years before diagnosis, number of comorbidities before diagnosis, smoking history, stage, estrogen receptor status, and histologic type of breast cancer tumor
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