Table 1 Gene Ontology (GO) functional terms and KEGG pathways significantly enriched considering 158 genes differentially expressed after miR-182 inhibition in both cell lines. BP, Biological Process; CC, Cellular Component; MF, Molecular Function
Functional category | Term/Pathway | Gene symbol | Genes | Fold Enrich. | Adj. p-value |
|---|---|---|---|---|---|
GO BP | Regulation of transcription, DNA-templated | ITGB3BP, EID3, SRSF10, EID2B, PPHLN1, ZNF557, SPTY2D1, NR3C1, ZNF638, ZNF655, ZNF165, ZFP36L1, SRRT, SFSWAP, ZNF181, ZNF226, HIF1A, PNRC2, THAP1, TCF3, NFIA, ZNF267, ZNF101 | 23 | 2.52 | 0.027 |
Positive regulation of apoptotic process | ITGB3BP, HIF1A, SQSTM1, TRIO, GADD45B, VAV2, GADD45A, LATS1, BCL2L11, IP6K2, PHLDA1 | 11 | 5.21 | 0.0333 | |
GO CC | Nucleus | ITGB3BP, TUBB2A, EID2B, CLK1, HIST2H4A, TCEAL1, CAMKK2, NFATC2IP, FUBP1, SFSWAP, CCNE1, ZNF181, BLZF1, CLK4, ANKRD11, NSMCE2, AKIRIN1, IP6K2, ZNF101, TIGD1, RELB, CCNL1, NABP1, HIF1A, MSANTD4, CUX1, GADD45B, GADD45A, SRSF10, SLF2, ZNF557, NR3C1, ZNF655, PXK, SESN2, TSPYL4, ZFP36L1, SFR1, VRK2, ZNF226, HIST1H4E, THAP1, TCF3, ZNF267, FKTN, TKT, ZNF165, RERG, CDKN1A, ATF3, ZBED4, PNRC2, RNPC3, PDCD6, PPP2R3C, NFIA | 56 | 1.53 | 0.0202 |
Nucleoplasm | ITGB3BP, EID3, SRSF10, NR3C1, ZNF638, HIST2H4A, TCEAL1, FUBP1, CCNE1, SRRT, BLZF1, SQSTM1, ANKRD11, HIST1H4E, NSMCE2, AKIRIN1, TCF3, AKT3, IP6K2, NQO2, PPP4R3B, PPHLN1, RELB, TKT, TRNT1, NABP1, CDKN1A, ATF3, HIF1A, SMARCC1, MAPK9, RNPC3, SCAF8, CUX1, GADD45A, NFIA | 36 | 1.94 | 0.0127 | |
GO MF | Protein binding | ITGB3BP, TUBB2A, CLK1, HIST2H4A, LATS1, RSRC2, FUBP1, SFSWAP, CCNE1, BLZF1, CLK4, ARL14, RABGEF1, NSMCE2, AKIRIN1, AKT3, ZNF101, NQO2, IP6K2, RAP2A, TTC32, RELB, CCNL1, RBKS, CCT6A, C8ORF44-SGK3, MRM1, BCL2L11, NABP1, HIF1A, NUCB2, USO1, MAPK9, G0S2, MAPRE2, GADD45B, SCAF8, GADD45A, EID3, SRSF10, SLC38A9, SNX5, CALD1, SLF2, RPS15A, FAM122A, FKBP1A, NR3C1, C6ORF226, ZNF655, TSPYL4, PPCDC, SESN2, ZFC3H1, ZFP36L1, SRRT, SFR1, VRK2, C1ORF50, KLC1, SQSTM1, HIST1H4E, LETMD1, THAP1, TCF3, INPP5A, PHLDA1, CCNB1IP1, RBM12B, PPHLN1, ASXL1, TRIO, TKT, RCAN3, VAV2, SGTB, ATG3, RPL28, ZNF165, PPIF, CDKN1A, C1ORF116, ATF3, SMARCC1, PNRC2, ZBED4, RIT1, AGR2, PDCD6, ALG13, PPP2R3C | 91 | 1.46 | 1.05E-05 |
KEGG | FoxO signaling pathway | CDKN1A, MAPK9, GADD45B, C8ORF44-SGK3, GADD45A, AKT3, BCL2L11 | 7 | 8.31 | 0.0185 |
p53 signaling pathway | CCNE1, CDKN1A, GADD45B, SESN2, GADD45A | 5 | 11.86 | 0.0434 |