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Table 1 Patient characteristics (n = 68)

From: Prognostic factors of brain metastases from colorectal cancer

Characteristic Category No. of patients (%)
Sex Male 43 (63%)
Female 25 (37%)
Age at the time of brain metastases (years) < 65 33 (49%)
≥65 35 (51%)
Location of primary tumor Colon 42 (62%)
Rectum 26 (38%)
Time interval from diagnosis of primary tumor to brain metastases Synchronous 14 (21%)
Metachronous 54 (79%)
Karnofsky performance status score ≥70 27 (40%)
< 70 (≤60) 41 (60%)
Presence of extracranial metastases Absent (Brain only) 14 (21%)
Present (Brain and other sites) 54 (79%)
Control of primary tumor Controlled 57 (84%)
Uncontrolled 11 (16%)
Maximum diameter of brain metastases < 3 cm 40 (59%)
≥3 cm 28 (41%)
Number of brain metastases Limited: 1–3 42 (62%)
Multiple: ≥4 26 (38%)
Interval from diagnosis of primary tumor to brain metastases < 12 months 17 (25%)
≥12 months 51 (75%)
Location of brain lesions Supratentorial 39 (57%)
Infratentorial 11 (16%)
Both 18 (27%)
History of systemic chemotherapy before diagnosis of brain metastases None 22 (32%)
Fluoropyrimidine only 13 (19%)
Fluoropyrimidine + oxaliplatin 6 (9%)
Fluoropyrimidine + irinotecan 6 (9%)
Fluoropyrimidine + oxaliplatin + irinotecan 21 (31%)