Fig. 7
From: VEGF-C induced by TGF- β1 signaling in gastric cancer enhances tumor-induced lymphangiogenesis
TGF- β1 promotes tumor growth and lymphangiogenesis in mouse xenograft model. a TGF-β1 inhibitor reduces tumor volume in MNK45 xenograft mouse model. b TGF-β1 inhibitor reduces tumor volume in KATOIII xenograft mouse model. c TGF-β1 inhibitor reduces the volume of xenograft model in dose-dependent manner. d Lymphovascular density with D2–40 immunohistochemistry. LY2157299 inhibits lymphangigoenesis in both types of gastric cancer tissue. (*P < 0.05, **P < 0.01, Mann-Whitney test)