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Table 3 Univariate and multivariate analyses of prognostic factors for overall survival in AML patients

From: Circ-Foxo3 is positively associated with the Foxo3 gene and leads to better prognosis of acute myeloid leukemia patients

Whole patients Univariate Multivariate
HR (95% CI) Exp. P value HR (95% CI) Exp. P value
Flt3-ITD 0.575–2.330 1.158 0.681 0.885–2.330 1.435 0.295
NPM1 1.044–5.017 2.289 0.039 0.471–3.644 1.309 0.606
CEBPA 0.515–2.253 1.077 0.843 0.402–3.666 1.215 0.730
WBC count 1.891–4.505 2.918 < 0.001 0.804–2.571 1.437 0.221
Karyotypic classification 1.628–2.763 2.121 < 0.001 1.113–2.188 1.561 0.010
Foxo3 expression 0.499–1.156 0.762 0.210 0.341–0.951 0.569 0.031
Circ-Foxo3 expression 0.650–1.661 1.039 0.873 0.664–2.200 1.208 0.536
Age 2.274–5.538 3.549 < 0.001 1.854–5.523 3.200 < 0.001