Table 3 Hereditary demographics, risk factors, and tumor characteristics
Variable | BRCA mutation carriers n = 21 | Non-carriers n = 80 | |
|---|---|---|---|
Age: m (SD) | 35.6 (4.5) | 37.3 (5.4) | p = 0.18 |
Family history of cancer | 66.6% | 50.0% | p = 0.17 |
Body mass index, m (SD) | 27.8 (5.0) | 27.7 (5.5) | p = 0.94 |
Age at menarche m (SD) | 12.1 (2.9) | 12.1 (1.7) | p = 1.00 |
No. pregnancy m (SD) | 2.4 (2.1) | 2.3 (1.5) | p = 0.80 |
Nulligravid (%) | 19.0% | 17.7% | p = 0.89 |
Age at first birth, m (SD) | 20.7 (4.9) | 21.6 (5.6) | p = 0.50 |
Breastfeeding % | 35.2% | 59.3% | p = 0.04 |
Contraception (%) | 40% | 37.9% | p = 0.86 |
Smoking (%) | 14.2% | 17.5% | p = 0.72 |
Histology, ductal. (%) | 88% | 89% | p = 0.90 |
Nuclear grade. (%) | |||
2 | 27% | 41.5% | p = 0.28 |
3 | 67% | 49.2% | p = 0.22 |
Stage. (%) | |||
0 | 4.7% | 0% | p = 0.0002 |
I-II | 71.4% | 52.5% | p = 0.12 |
III | 23.8% | 42.5% | p = 0.11 |
IV | 0% | 5% | p = 0.29 |
T | |||
0–1 | 19% | 31.6% | p = 0.26 |
2 | 57% | 31.6% | p = 0.03 |
3 | 19% | 26.6% | p = 0.47 |
4 | 4.7% | 10.2% | p = 0.43 |
N Positive | 50% | 62% | p = 0.33 |
IHC | |||
ER (+) | 30% | 60.5% | p = 0.01 |
PR (+) | 30% | 53.9% | p = 0.058 |
HER (+) | 16% | 21.6% | p = 0.57 |
Triple Negative. | 65% | 22.6% | p = < 0.001 |