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Table 3 Hereditary demographics, risk factors, and tumor characteristics

From: Analysis of the pathogenic variants of BRCA1 and BRCA2 using next-generation sequencing in women with familial breast cancer: a case–control study

Variable BRCA mutation carriers n = 21 Non-carriers n = 80  
Age: m (SD) 35.6 (4.5) 37.3 (5.4) p = 0.18
Family history of cancer 66.6% 50.0% p = 0.17
Body mass index, m (SD) 27.8 (5.0) 27.7 (5.5) p = 0.94
Age at menarche m (SD) 12.1 (2.9) 12.1 (1.7) p = 1.00
No. pregnancy m (SD) 2.4 (2.1) 2.3 (1.5) p = 0.80
Nulligravid (%) 19.0% 17.7% p = 0.89
Age at first birth, m (SD) 20.7 (4.9) 21.6 (5.6) p = 0.50
Breastfeeding % 35.2% 59.3% p = 0.04
Contraception (%) 40% 37.9% p = 0.86
Smoking (%) 14.2% 17.5% p = 0.72
Histology, ductal. (%) 88% 89% p = 0.90
Nuclear grade. (%)
 2 27% 41.5% p = 0.28
 3 67% 49.2% p = 0.22
Stage. (%)
 0 4.7% 0% p = 0.0002
 I-II 71.4% 52.5% p = 0.12
 III 23.8% 42.5% p = 0.11
 IV 0% 5% p = 0.29
T
 0–1 19% 31.6% p = 0.26
 2 57% 31.6% p = 0.03
 3 19% 26.6% p = 0.47
 4 4.7% 10.2% p = 0.43
N Positive 50% 62% p = 0.33
 IHC
 ER (+) 30% 60.5% p = 0.01
 PR (+) 30% 53.9% p = 0.058
 HER (+) 16% 21.6% p = 0.57
 Triple Negative. 65% 22.6% p = < 0.001
  1. m mean, SD standard deviation, IHC immunohistochemical analysis, ER estrogen receptor, PR progesterone receptor