Training set | Internal validation set | External validation set | ||||
---|---|---|---|---|---|---|
Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |
Univariate | ||||||
ER-α | ||||||
High vs. low | 5.221 (2.073–13.146) | < 0.001* | 1.596 (1.020–2.497) | 0.039* | 1.774 (1.145–2.749) | 0.02* |
PR | ||||||
High vs. low | 0.869 | |||||
Multivariate | ||||||
Age | ||||||
> 60y vs. ≤60y | 0.462 (0.178–1.196) | 0.112 | 1.111 (0.762–1.621) | 0.584 | 2.029 (1.149–3.585) | 0.015* |
Gender | ||||||
Female vs. male | 1.143 (0.427–3.062) | 0.790 | 0.890 (0.605–1.309) | 0.554 | 1.154 (0.747–1.781) | 0.519 |
Stage | ||||||
Stage II- III vs. I | 2.841 (1.230–6.558) | 0.014* | 1.715 (1.287–2.287) | 0.000* | 2.654 (1.153–6.110) | 0.022* |
Localization | ||||||
Rectum vs. colon | 0.909 (0.354–2.333) | 0.842 | 1.861 (1.271–2.727) | 0.001* | 1.140 (0.667–1.947) | 0.632 |
ER-α | ||||||
High vs. low | 5.061 (1.833–13.968) | 0.002* | 1.572 (1.001–2.467) | 0.049* | 1.624 (1.047–2.520) | 0.031* |