Skip to main content

Table 2 Overall survival analyses for training and validation cohorts

From: Prognostic value of estrogen receptor-α and progesterone receptor in curatively resected colorectal cancer: a retrospective analysis with independent validations

  Training set Internal validation set External validation set
Hazard ratio
(95% CI)
P value Hazard ratio
(95% CI)
P value Hazard ratio
(95% CI)
P value
Univariate
 ER-α
  High vs. low 5.221 (2.073–13.146) < 0.001* 1.596 (1.020–2.497) 0.039* 1.774 (1.145–2.749) 0.02*
 PR
  High vs. low   0.869     
Multivariate
 Age
  > 60y vs. ≤60y 0.462 (0.178–1.196) 0.112 1.111 (0.762–1.621) 0.584 2.029 (1.149–3.585) 0.015*
 Gender
  Female vs. male 1.143 (0.427–3.062) 0.790 0.890 (0.605–1.309) 0.554 1.154 (0.747–1.781) 0.519
 Stage
  Stage II- III vs. I 2.841 (1.230–6.558) 0.014* 1.715 (1.287–2.287) 0.000* 2.654 (1.153–6.110) 0.022*
 Localization
  Rectum vs. colon 0.909 (0.354–2.333) 0.842 1.861 (1.271–2.727) 0.001* 1.140 (0.667–1.947) 0.632
 ER-α
  High vs. low 5.061 (1.833–13.968) 0.002* 1.572 (1.001–2.467) 0.049* 1.624 (1.047–2.520) 0.031*
  1. Uni- and multivariate survival analyses for risk of death. Hazard ratios were calculated by the adjusted Cox proportional hazards model
  2. Abbreviations: ER-α estrogen receptor –α, PR progesterone receptor
  3. *statistically significant
\