| Adjuvant chemotherapy for stage III colon cancer | |||
---|---|---|---|---|
3A. Univariate analysis | 3B. Multivariate analysis | |||
n (%) | P value | Odds Ratio (95% CI) | P value | |
Age, years | ||||
  < 65 | 226 (91.9) | < 0.0005b | 1 |  |
 65–80 | 239 (76.8) |  | 0.3 (0.1–0.6) | 0.001 |
  > 80 | 26 (26.8) |  | 0.04 (0.02–0.09) | < 0.0005 |
Sex | ||||
 Male | 309 (74.3) | 0.57a |  |  |
 Female | 182 (76.5) |  |  |  |
Deprivation index | ||||
 Quartile 1 | 106 (79.7) | 0.29b |  |  |
 Quartile 2 | 142 (72.4) |  |  |  |
 Quartile 3 | 121 (75.2) |  |  |  |
 Quartile 4 | 97 (72.4) |  |  |  |
Level of education | ||||
 No formal | 47 (66.2) | < 0.0005b | 1 |  |
 Primary | 253 (75.5) |  | 1.2 (0.7–2.2) | 0.46 |
 Secondary | 53 (85.5) |  | 1.6 (0.4–5.5) | 0.46 |
 University | 59 (89.4) |  | 1.6 (0.5–5.7) | 0.45 |
Living arrangement | ||||
 Living alone | 56 (70.9) | 0.2a |  |  |
 Living with others | 345 (77.9) |  |  |  |
Family history of cancer | ||||
 No | 257 (71.2) | < 0.0005a | 1 |  |
 Yes | 194 (87.0) |  | 1.9 (0.7–5.0) | 0.21 |
Screening | ||||
 No | 368 (72.2) | 0.001a | 1 |  |
 Yes | 97 (86.6) |  | 1.0 (0.4–2.2) | 0.99 |
Smoking habits | ||||
 Never smoker | 241 (76.3) | 0.516a |  |  |
 Current smoker | 61 (79.2) |  |  |  |
 Ex-smoker | 187 (73.3) |  |  |  |
Alcohol | ||||
 No | 392 (74.1) | 0.42a |  |  |
 Yes | 63 (75.9) |  |  |  |
Charlson index | ||||
 0 | 296 (82.0) | < 0.0005b | 1 |  |
 1 | 114 (73.5) |  | 0.8 (0.5–1.4) | 0.43 |
  ≥ 2 | 81 (58.7) |  | 0.6 (0.3–1.2) | 0.17 |
ASA class | ||||
 I-II | 309 (85.4) | < 0.0005b | 1 |  |
 III | 155 (64.9) |  | 0.6 (0.3–1.1) | 0.10 |
 IV | 10 (31.3) |  | 0.1 (0.03–0.3) | < 0.0005 |
Site | ||||
 Rectosigmoid junction | 78 (81.3) | 0.19a | 1 |  |
 Distal colon | 219 (75.8) |  | 0.5 (0.2–1.4) | 0.18 |
 Proximal colon | 194 (72.1) |  | 0.5 (0.2–1.6) | 0.25 |
Degree of differentiation | ||||
 Low grade | 354 (75.3) | 0.12a | 1 |  |
 High grade | 85 (82.5) |  | 1.2 (0.4–3.4) | 0.70 |
Histological classification | ||||
 Adenocarcinoma | 439 (75.7) | 0.29a |  |  |
 Mucinous Adenocarcinoma | 38 (73.1) |  |  |  |
 Signet-ring cell carcinoma | 8 (100.0) |  |  |  |
 Other carcinomas | 3 (100.0) |  |  |  |
Cancer committee | ||||
 No | 180 (72.6) | 0.30a |  |  |
 Yes | 282 (76.4) |  |  |  |
Surgeon’s profile | ||||
 General | 134 (69.4) | 0.07a | 1 |  |
 Coloproctologist | 323 (76.5) |  | 1.3 (0.6–3.1) | 0.50 |
Curative resection | ||||
 R0 | 428 (76.0) | 0.62a |  |  |
 R1/R2 | 40 (72.7) |  |  |  |