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Table 3 Crude and adjusted analysis of the association between age and adjuvant chemotherapy in stage III colon cancer

From: Impact of age on the use of adjuvant treatments in patients undergoing surgery for colorectal cancer: patients with stage III colon or stage II/III rectal cancer

 Adjuvant chemotherapy for stage III colon cancer
3A. Univariate analysis3B. Multivariate analysis
n (%)P valueOdds Ratio (95% CI)P value
Age, years
  < 65226 (91.9)< 0.0005b1 
 65–80239 (76.8) 0.3 (0.1–0.6)0.001
  > 8026 (26.8) 0.04 (0.02–0.09)< 0.0005
Sex
 Male309 (74.3)0.57a  
 Female182 (76.5)   
Deprivation index
 Quartile 1106 (79.7)0.29b  
 Quartile 2142 (72.4)   
 Quartile 3121 (75.2)   
 Quartile 497 (72.4)   
Level of education
 No formal47 (66.2)< 0.0005b1 
 Primary253 (75.5) 1.2 (0.7–2.2)0.46
 Secondary53 (85.5) 1.6 (0.4–5.5)0.46
 University59 (89.4) 1.6 (0.5–5.7)0.45
Living arrangement
 Living alone56 (70.9)0.2a  
 Living with others345 (77.9)   
Family history of cancer
 No257 (71.2)< 0.0005a1 
 Yes194 (87.0) 1.9 (0.7–5.0)0.21
Screening
 No368 (72.2)0.001a1 
 Yes97 (86.6) 1.0 (0.4–2.2)0.99
Smoking habits
 Never smoker241 (76.3)0.516a  
 Current smoker61 (79.2)   
 Ex-smoker187 (73.3)   
Alcohol
 No392 (74.1)0.42a  
 Yes63 (75.9)   
Charlson index
 0296 (82.0)< 0.0005b1 
 1114 (73.5) 0.8 (0.5–1.4)0.43
  ≥ 281 (58.7) 0.6 (0.3–1.2)0.17
ASA class
 I-II309 (85.4)< 0.0005b1 
 III155 (64.9) 0.6 (0.3–1.1)0.10
 IV10 (31.3) 0.1 (0.03–0.3)< 0.0005
Site
 Rectosigmoid junction78 (81.3)0.19a1 
 Distal colon219 (75.8) 0.5 (0.2–1.4)0.18
 Proximal colon194 (72.1) 0.5 (0.2–1.6)0.25
Degree of differentiation
 Low grade354 (75.3)0.12a1 
 High grade85 (82.5) 1.2 (0.4–3.4)0.70
Histological classification
 Adenocarcinoma439 (75.7)0.29a  
 Mucinous Adenocarcinoma38 (73.1)   
 Signet-ring cell carcinoma8 (100.0)   
 Other carcinomas3 (100.0)   
Cancer committee
 No180 (72.6)0.30a  
 Yes282 (76.4)   
Surgeon’s profile
 General134 (69.4)0.07a1 
 Coloproctologist323 (76.5) 1.3 (0.6–3.1)0.50
Curative resection
 R0428 (76.0)0.62a  
 R1/R240 (72.7)   
  1. aPearson Chi-square test
  2. bChi-square test for trends