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Table 3 Crude and adjusted analysis of the association between age and adjuvant chemotherapy in stage III colon cancer

From: Impact of age on the use of adjuvant treatments in patients undergoing surgery for colorectal cancer: patients with stage III colon or stage II/III rectal cancer

 

Adjuvant chemotherapy for stage III colon cancer

3A. Univariate analysis

3B. Multivariate analysis

n (%)

P value

Odds Ratio (95% CI)

P value

Age, years

  < 65

226 (91.9)

< 0.0005b

1

 

 65–80

239 (76.8)

 

0.3 (0.1–0.6)

0.001

  > 80

26 (26.8)

 

0.04 (0.02–0.09)

< 0.0005

Sex

 Male

309 (74.3)

0.57a

  

 Female

182 (76.5)

   

Deprivation index

 Quartile 1

106 (79.7)

0.29b

  

 Quartile 2

142 (72.4)

   

 Quartile 3

121 (75.2)

   

 Quartile 4

97 (72.4)

   

Level of education

 No formal

47 (66.2)

< 0.0005b

1

 

 Primary

253 (75.5)

 

1.2 (0.7–2.2)

0.46

 Secondary

53 (85.5)

 

1.6 (0.4–5.5)

0.46

 University

59 (89.4)

 

1.6 (0.5–5.7)

0.45

Living arrangement

 Living alone

56 (70.9)

0.2a

  

 Living with others

345 (77.9)

   

Family history of cancer

 No

257 (71.2)

< 0.0005a

1

 

 Yes

194 (87.0)

 

1.9 (0.7–5.0)

0.21

Screening

 No

368 (72.2)

0.001a

1

 

 Yes

97 (86.6)

 

1.0 (0.4–2.2)

0.99

Smoking habits

 Never smoker

241 (76.3)

0.516a

  

 Current smoker

61 (79.2)

   

 Ex-smoker

187 (73.3)

   

Alcohol

 No

392 (74.1)

0.42a

  

 Yes

63 (75.9)

   

Charlson index

 0

296 (82.0)

< 0.0005b

1

 

 1

114 (73.5)

 

0.8 (0.5–1.4)

0.43

  ≥ 2

81 (58.7)

 

0.6 (0.3–1.2)

0.17

ASA class

 I-II

309 (85.4)

< 0.0005b

1

 

 III

155 (64.9)

 

0.6 (0.3–1.1)

0.10

 IV

10 (31.3)

 

0.1 (0.03–0.3)

< 0.0005

Site

 Rectosigmoid junction

78 (81.3)

0.19a

1

 

 Distal colon

219 (75.8)

 

0.5 (0.2–1.4)

0.18

 Proximal colon

194 (72.1)

 

0.5 (0.2–1.6)

0.25

Degree of differentiation

 Low grade

354 (75.3)

0.12a

1

 

 High grade

85 (82.5)

 

1.2 (0.4–3.4)

0.70

Histological classification

 Adenocarcinoma

439 (75.7)

0.29a

  

 Mucinous Adenocarcinoma

38 (73.1)

   

 Signet-ring cell carcinoma

8 (100.0)

   

 Other carcinomas

3 (100.0)

   

Cancer committee

 No

180 (72.6)

0.30a

  

 Yes

282 (76.4)

   

Surgeon’s profile

 General

134 (69.4)

0.07a

1

 

 Coloproctologist

323 (76.5)

 

1.3 (0.6–3.1)

0.50

Curative resection

 R0

428 (76.0)

0.62a

  

 R1/R2

40 (72.7)

   
  1. aPearson Chi-square test
  2. bChi-square test for trends