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Table 1 Parameters estimated for the LMM (Eq. 3) of the cisplatin dataset

From: The design, analysis and application of mouse clinical trials in oncology drug development

Fixed-Effect Parameters Estimate* p-value
β0 (Intercept) 5.2641 (0.0257) 0
β1 (Day) 0.0605 (0.0043) 1.5E-43
β2 (Day × CancerTypeGA) 0.0091 (0.0055) 0.098
β3 (Day × CancerTypeLU) 0.0297 (0.0071) 2.8E-5
β4 (Day × Treatment) −0.0282 (0.0031) 1.2E-19
β5 (Day × CancerTypeGA × Treatment) 0.0037 (0.0039) 0.35
β6 (Day × CancerTypeLU × Treatment) −0.0011 (0.0052) 0.84
  1. *parameters estimated by the REML method in the R nlme package