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Fig. 4 | BMC Cancer

Fig. 4

From: SREBP1 promotes the invasion of colorectal cancer accompanied upregulation of MMP7 expression and NF-κB pathway activation

Fig. 4

The role of p65 phosphorylation in MMP7 and SREBP1 increased concomitantly. SREBP1 promotes the expression of MMP7 and activates phosphorylation of NF-κB protein p65. a, b the relationship between SREBP1 and MMP7 tested by western bolt. c, d the relationship between SREBP1 and P-65. e, f NF-κB inhibitor SN50 can inhibit the expression of MMP7. (HT29 SREBP1oe that over-expressed SREBP1 in the HT29 cell line is represented by HT29+, SW620 SREBP1kd that had stably knocked down SREBP1 in the SW620 cell line is represented by SW620-)

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