Fig. 2

Detection of the invasive capability of CRC infected by SREBP1. a, b, c invasive tumor cells that highly expressing SREBP1 significantly outnumber those cells which express normal-level SREBP1 in transwell experiment (HT29 vs HT29 SREBP1^oe: 18.33 ± 0.88 vs 44.83 ± 1.58, P < 0.0001) (SW620 vs SW620 SREBP1^kd, 31.67 ± 0.88 vs 9.83 ± 0.95, P < 0.0001). d HUVEC cells co-cultured with the culture supernatant of the over-expressing HT29 SREBP1^oe cells, SW620 SREBP1^kd cells or control cells for 48 h. e the total length, number of branches and the number of nodes in HT29 SREBP1^oe, compared with HT29 (P_{tol NO.} = 0.023, P_{tol branches} = 0.076, P_{tol nodes} = 0.312). f the total length, number of branches and the number of nodes in SW620 compared with SW620- (P_{tol NO.} = 0.0376, P_{tol branches} = 0.0007, P_{tol nodes} = 0.0140). (HT29 SREBP1^oe that over-expressed SREBP1 in the HT29+ cell line is represented by HT29+, SW620 SREBP1^kd that had stably knocked down SREBP1 in the SW620 cell line is represented by SW620-)