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Table 3 Multivariable Cox regression analysis of KLK5 mRNA expression levels and patients survival in advanced HGSOC stage FIGO III/IV

From: Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer

Clinical parameters

OS

PFS

No a

HR (95% CI) b

p

No a

HR (95% CI) b

p

Age

  

0.660

  

0.592

 ≤ 60 years

46

1

 

41

1

 

 > 60 years

63

1.13 (0.65–1.96)

 

57

0.87 (0.53–1.44)

 

Residual tumor mass

  

< 0.001

  

0.005

 0 mm

59

1

 

57

1

 

 > 0 mm

50

3.29 (1.69–6.41)

 

41

2.20 (1.17–3.81)

 

Ascitic fluid volume

  

0.605

  

0.363

 ≤ 500 ml

64

1

 

60

1

 

 > 500 ml

45

1.18 (0.64–1.91)

 

38

1.33 (0.76–2.31)

 

KLK5 mRNA c

  

0.718

  

0.095

 low

69

1

 

59

1

 

 high

40

1.11 (0.64–1.91)

 

39

1.53 (0.93–2.51)

 
  1. The biological marker KLK5 mRNA was added to the base model of clinical parameters: age, residual tumor mass, and ascites fluid volume. Significant p-values (p < 0.05) are indicated in bold
  2. a Number of patients;
  3. b HR: hazard ratio (CI: confidence interval) of multivariable Cox regression analysis;
  4. c Dichotomized into low and high levels by tertiles 1 + 2 versus tertile 3