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Table 3 Multivariable Cox regression analysis of KLK5 mRNA expression levels and patients survival in advanced HGSOC stage FIGO III/IV

From: Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer

Clinical parameters OS PFS
No a HR (95% CI) b p No a HR (95% CI) b p
Age    0.660    0.592
 ≤ 60 years 46 1   41 1  
 > 60 years 63 1.13 (0.65–1.96)   57 0.87 (0.53–1.44)  
Residual tumor mass    < 0.001    0.005
 0 mm 59 1   57 1  
 > 0 mm 50 3.29 (1.69–6.41)   41 2.20 (1.17–3.81)  
Ascitic fluid volume    0.605    0.363
 ≤ 500 ml 64 1   60 1  
 > 500 ml 45 1.18 (0.64–1.91)   38 1.33 (0.76–2.31)  
KLK5 mRNA c    0.718    0.095
 low 69 1   59 1  
 high 40 1.11 (0.64–1.91)   39 1.53 (0.93–2.51)  
  1. The biological marker KLK5 mRNA was added to the base model of clinical parameters: age, residual tumor mass, and ascites fluid volume. Significant p-values (p < 0.05) are indicated in bold
  2. a Number of patients;
  3. b HR: hazard ratio (CI: confidence interval) of multivariable Cox regression analysis;
  4. c Dichotomized into low and high levels by tertiles 1 + 2 versus tertile 3