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Table 2 Univariate Cox regression analysis of KLK5 mRNA expression levels and patients’ survival in advanced HGSOC stage FIGO III/IV

From: Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer

Clinical parameters

OS

PFS

No a

HR (95% CI) b

p

No a

HR (95% CI) b

p

Age

  

0.414

  

0.762

 ≤ 60 years

49

1

 

43

1

 

 > 60 years

70

1.24 (0.74–2.06)

 

62

1.08 (0.67–1.72)

 

Residual tumor mass

  

< 0.001

  

< 0.001

 0 mm

60

1

 

58

1

 

 > 0 mm

57

3.80 (2.17–6.65)

 

47

2.41 (1.53–3.90)

 

Ascites fluid volume

  

0.005

  

0.019

 ≤ 500 ml

66

1

 

61

1

 

 > 500 ml

46

2.10 (1.25–3.54)

 

38

1.79 (1.10–2.90)

 

FIGO stage

  

0.215

  

0.360

 IIIA + IIIB

13

1

 

12

1

 

 IIIC + IV

106

1.90 (0.69–5.24)

 

93

1.44 (0.63–3.14)

 

KLK5 mRNA c

  

0.269

  

0.047

 low

73

1

 

62

1

 

 high

45

1.33 (0.80–2.20)

 

42

1.60 (1.01–2.55)

 
  1. Significant p-values (p < 0.05) are indicated in bold. Due to missing values, numbers do not always add up to n = 119 (OS) and n = 105 (PFS)
  2. a Number of patients;
  3. b HR: hazard ratio (CI: confidence interval) of univariate Cox regression analysis;
  4. c Dichotomized into low and high levels by tertiles 1 + 2 versus tertile 3;