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Table 2 Univariate Cox regression analysis of KLK5 mRNA expression levels and patients’ survival in advanced HGSOC stage FIGO III/IV

From: Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer

Clinical parameters OS PFS
No a HR (95% CI) b p No a HR (95% CI) b p
Age    0.414    0.762
 ≤ 60 years 49 1   43 1  
 > 60 years 70 1.24 (0.74–2.06)   62 1.08 (0.67–1.72)  
Residual tumor mass    < 0.001    < 0.001
 0 mm 60 1   58 1  
 > 0 mm 57 3.80 (2.17–6.65)   47 2.41 (1.53–3.90)  
Ascites fluid volume    0.005    0.019
 ≤ 500 ml 66 1   61 1  
 > 500 ml 46 2.10 (1.25–3.54)   38 1.79 (1.10–2.90)  
FIGO stage    0.215    0.360
 IIIA + IIIB 13 1   12 1  
 IIIC + IV 106 1.90 (0.69–5.24)   93 1.44 (0.63–3.14)  
KLK5 mRNA c    0.269    0.047
 low 73 1   62 1  
 high 45 1.33 (0.80–2.20)   42 1.60 (1.01–2.55)  
  1. Significant p-values (p < 0.05) are indicated in bold. Due to missing values, numbers do not always add up to n = 119 (OS) and n = 105 (PFS)
  2. a Number of patients;
  3. b HR: hazard ratio (CI: confidence interval) of univariate Cox regression analysis;
  4. c Dichotomized into low and high levels by tertiles 1 + 2 versus tertile 3;