Fig. 4

Blue module mRNAs represent a class of early EMT markers. a Network connection of the most highly connected genes in the blue module. Blue lines indicate positive expression correlation, and red line indicates negative expression correlation. Pink circles indicate transmembrane transporters in this module. b-f RT-qPCR results of mRNA levels of key blue module genes in CAF treated and control A549 cells at different time points. Error bars are SD. *, p < 0.05; **, p < 0.01; t-test