Table 2 Bivariate analysis, very early relapse and early mortality during the first 24 months after diagnosis
Variable | Very early relapse | Early mortality | ||||
|---|---|---|---|---|---|---|
# events | RR | IC 95% | # events | RR | IC 95% | |
Sex | ||||||
Female (ref.) | 54 | 1 | – | 103 | 1 | – |
Male | 106 | 1.7 | 1.2–2.4 | 110 | 0.8 | 0.6–1.1 |
Age | ||||||
1–9.9 years (ref.) | 92 | 1 | – | 111 | 1 | – |
< 1 year | 8 | 2.7 | 1.2–6.4 | 15 | 6.4 | 2.9–13.8 |
≥ 10 years | 60 | 1.6 | 1.1–2.3 | 87 | 2.1 | 1.5–2.9 |
NCI risk classification | ||||||
Standard (ref.) | 66 | 1 | – | 81 | 1 | – |
High | 94 | 1.9 | 1.4–2.8 | 132 | 2.5 | 1.8–3.3 |
Immunophenotype | ||||||
Pre-B (ref.) | 138 | 1 | – | 173 | 1 | – |
B mature | 4 | 1.8 | 0.6–5.9 | 3 | 0.9 | 0.3–3.5 |
Biphenotypic | 5 | 0.8 | 0.3–2.3 | 7 | 1.0 | 0.4–2.3 |
T Cell | 13 | 0.8 | 0.4–1.5 | 30 | 1.8 | 1.1–2.8 |
Socioeconomic Status | ||||||
High (ref.) | 32 | 1 | – | 32 | 1 | – |
Low-medium | 127 | 0.6 | 0.4–0.9 | 173 | 0.9 | 0.6–1.3 |
Nutritional status | ||||||
CDC (percentiles) | ||||||
Normal (p5–84.9) (ref.) | 79 | 1 | – | 95 | 1 | – |
Overweight (p85–94.9) | 19 | 1.1 | 0.6–1.9 | 29 | 1.5 | 0.9–2.4 |
Obesity (≥ p95) | 25 | 1.4 | 0.8–2.2 | 39 | 1.9 | 1.3–3.0 |
WHO (Z-score) | ||||||
Normal (−1.9–0.9) (ref.) | 96 | 1 | – | 118 | 1 | – |
At risk of overweight (1–1.9) | 28 | 0.9 | 0.6–1.5 | 45 | 1.4 | 0.9–2.0 |
Overweight (2–2.9) | 18 | 1.4 | 0.8–2.4 | 25 | 1.6 | 1.0–2.7 |
Obesity (≥3) | 8 | 1.3 | 0.6–2.8 | 12 | 1.7 | 0.8–3.3 |