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Table 3 Clinicopathological parameters correlated to RELA fusions in intracranial ependymal tumors

From: Clinical significance of the histological and molecular characteristics of ependymal tumors: a single institution case series from China

  RELA fusions present P value
Age   0.002
 ≤ 18 years 13/21
 > 18 years 4/24
Gender   
 Male 11/25 0.336
 Female 6/20  
WHO grade   
 Grade II 1/15 0.008
 Grade III 16/30  
Cellularity   
 low 1/5 0.047
 moderate 2/12  
 high 11/19  
Cellular atypia   
 mild 1/9 0.029
 moderate 4/13  
 severe 9/14  
Vascular proliferation   
 absent 3/19 0.003
 present 11/17  
 Mitosis   
 ≤ 5/2mm2 4/19 0.020
 > 5/2mm2 10/17  
Necrosis   
 absent 2/15 0.008
 present 12/21  
Ki67 index   
 ≤ 6% 2/23 <0.001
 > 6% 12/16  
CCND1 amplification   
 present 5/14 0.800
 absent 8/20  
  1. *: Some cases were lost due to inadequate tissue for testing or other reasons