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Table 2 Cox proportional hazards models for LRFS

From: Development of nomograms for prognostication of patients with primary soft tissue sarcomas of the trunk and extremity: report from the Bone and Soft Tissue Tumor Registry in Japan

  Univariate analysis Multivariate analysis
  Hazard ratio (95% CI) P value Hazard ratio (95% CI) P value
Age
  < 30 Reference   Reference  
 30–49 0.80 (0.41–1.55) 0.505 0.82 (0.41–1.61) 0.557
 50–69 1.26 (0.69–2.30) 0.450 0.99 (0.52–1.88) 0.971
 70- 1.59 (0.88–2.90) 0.126 1.25 (0.65–2.39) 0.500
Sex
 Male Reference   Reference  
 Female 0.86 (0.66–1.11) 0.238 1.05 (0.81–1.36) 0.729
Site
 Lower extremity Reference   Reference  
 Upper extremity 1.31 (0.91–1.89) 0.142 1.46 (1.01–2.12) 0.045
 Trunk 3.06 (2.32–4.05) < 0.001 2.55 (1.91–3.41) < 0.001
Depth
 Superficial Reference   Reference  
 Deep 2.16 (1.52–3.06) < 0.001 1.33 (0.91–1.94) 0.139
Size
 5 cm< Reference   Reference  
 5 cm≤, < 10 cm 2.14 (1.45–3.16) < 0.001 1.95 (1.31–2.92) 0.001
 10 cm≤ 4.19 (2.87–6.13) < 0.001 3.50 (2.31–5.32) < 0.001
Histological diagnosis
 MLS Reference   Reference  
 LMS 4.51 (2.15–9.47) < 0.001 3.10 (1.43–6.69) 0.004
 DDLS 7.20 (3.48–14.9) < 0.001 2.58 (1.20–5.54) 0.015
 MFS 5.77 (2.57–12.94) < 0.001 3.46 (1.51–7.94) 0.003
 MPNST 3.24 (1.53–6.84) 0.002 2.46 (1.13–5.34) 0.023
 SySa 2.05 (0.81–5.16) 0.128 1.47 (0.57–3.79) 0.430
 UPS 3.17 (1.57–6.37) 0.001 1.99 (0.96–4.13) 0.065
 Angiosarcoma 7.34 (1.99–27.13) 0.003 4.95 (1.32–18.58) 0.018
 PLS 1.99 (0.61–6.46) 0.252 1.14 (0.35–3.75) 0.828
 Others 3.50 (1.70–7.22) < 0.001 2.88 (1.37–6.07) 0.005
Histological grade
 Low Reference   Reference  
 High 2.93 (1.84–4.69) < 0.001 2.43 (1.48–3.99) < 0.001
Nodal meta
 Negative Reference   Reference  
 Positive 2.26 (1.12–4.57) 0.023 1.48 (0.70–3.10) 0.304
Surgical margin
 Negative Reference   Reference  
 Positive 4.29 (3.10–5.95) < 0.001 3.12 (2.22–4.37) < 0.001
  1. CI confidence interval, MLS myxoid liposarcoma, LMS leiomyosarcoma, DDLS dedifferentiated liposarcoma, MPNST malignant peripheral nerve sheath tumor, MFS myxofibrosarcoma, SySa synovial sarcoma, UPS undifferentiated pleomorphic sarcoma, PLS pleomorphic liposarcoma