Table 2 Cox proportional hazards models for LRFS
Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |
Age | ||||
< 30 | Reference | Reference | ||
30–49 | 0.80 (0.41–1.55) | 0.505 | 0.82 (0.41–1.61) | 0.557 |
50–69 | 1.26 (0.69–2.30) | 0.450 | 0.99 (0.52–1.88) | 0.971 |
70- | 1.59 (0.88–2.90) | 0.126 | 1.25 (0.65–2.39) | 0.500 |
Sex | ||||
Male | Reference | Reference | ||
Female | 0.86 (0.66–1.11) | 0.238 | 1.05 (0.81–1.36) | 0.729 |
Site | ||||
Lower extremity | Reference | Reference | ||
Upper extremity | 1.31 (0.91–1.89) | 0.142 | 1.46 (1.01–2.12) | 0.045 |
Trunk | 3.06 (2.32–4.05) | < 0.001 | 2.55 (1.91–3.41) | < 0.001 |
Depth | ||||
Superficial | Reference | Reference | ||
Deep | 2.16 (1.52–3.06) | < 0.001 | 1.33 (0.91–1.94) | 0.139 |
Size | ||||
5 cm< | Reference | Reference | ||
5 cm≤, < 10 cm | 2.14 (1.45–3.16) | < 0.001 | 1.95 (1.31–2.92) | 0.001 |
10 cm≤ | 4.19 (2.87–6.13) | < 0.001 | 3.50 (2.31–5.32) | < 0.001 |
Histological diagnosis | ||||
MLS | Reference | Reference | ||
LMS | 4.51 (2.15–9.47) | < 0.001 | 3.10 (1.43–6.69) | 0.004 |
DDLS | 7.20 (3.48–14.9) | < 0.001 | 2.58 (1.20–5.54) | 0.015 |
MFS | 5.77 (2.57–12.94) | < 0.001 | 3.46 (1.51–7.94) | 0.003 |
MPNST | 3.24 (1.53–6.84) | 0.002 | 2.46 (1.13–5.34) | 0.023 |
SySa | 2.05 (0.81–5.16) | 0.128 | 1.47 (0.57–3.79) | 0.430 |
UPS | 3.17 (1.57–6.37) | 0.001 | 1.99 (0.96–4.13) | 0.065 |
Angiosarcoma | 7.34 (1.99–27.13) | 0.003 | 4.95 (1.32–18.58) | 0.018 |
PLS | 1.99 (0.61–6.46) | 0.252 | 1.14 (0.35–3.75) | 0.828 |
Others | 3.50 (1.70–7.22) | < 0.001 | 2.88 (1.37–6.07) | 0.005 |
Histological grade | ||||
Low | Reference | Reference | ||
High | 2.93 (1.84–4.69) | < 0.001 | 2.43 (1.48–3.99) | < 0.001 |
Nodal meta | ||||
Negative | Reference | Reference | ||
Positive | 2.26 (1.12–4.57) | 0.023 | 1.48 (0.70–3.10) | 0.304 |
Surgical margin | ||||
Negative | Reference | Reference | ||
Positive | 4.29 (3.10–5.95) | < 0.001 | 3.12 (2.22–4.37) | < 0.001 |