Can pattern and depth of invasion predict lymph node relapse and prognosis in tongue squamous cell carcinoma

BMC Cancer

Table 3 Univariate and multivariate analyses on factors associated with TSCC prognosis

Items	N	Univariate analysis			Multi-variate analysis
Items	N	HR	95%CI	P value^*	HR	95%CI	P value^#
Gender
Male	75	Reference			Reference
Female	66	0.54	0.25–1.16	0.116	0.33	0.06–1.79	0.201
Age (years old)
< 55	59	Reference			Reference
≥ 55	82	1.74	0.79–3.82	0.168	3.9	1.29–11.82	0.016
Growth mode of invasive front
Crumb	79	Reference			Reference
Trabes	62	19.16	4.56–80.56	< 0.001	6.3	1.15–34.43	0.034
Depth of invasion
< 4 mm	43	Reference			Reference
≥ 4 mm	98	39.04	1.56–975.46	0.026	237,144.33	0.00–8.820E+ 118	0.926
Pathological differentiation
Well	48	Reference			Reference
Moderate/poor	93	2.69	0.94–7.75	0.066	0.913	0.20–4.09	0.905
Neurovascular invasion
No	123	Reference			Reference
Yes	18	4.04	1.88–8.69	< 0.001	0.48	0.19–1.24	0.129
Location
Anterior	14	Reference			Reference
Middle	103	1.32	0.31–5.73	0.709	2.51	0.45–14.03	0.296
Back	24	3.87	0.85–17.68	0.081	4.66	0.62–35.02	0.135
T stage
T1	60	Reference			Reference
T2	81	3.22	1.31–7.91	0.011	1.23	0.35–4.32	0.752
Smoking
No	82	Reference			Reference
Yes	59	2.16	1.03–4.52	0.042	0.00	0.00–2.917E+ 078	0.929
Drinking
No	89	Reference			Reference
Yes	52	2.82	1.34–5.91	0.006	2162.96	0.00–3.651E+ 085	0.937
Treatment
Observation	72	Reference			Reference
Neck dissection	69	1.24	0.60–2.58	0.565	0.96	0.40–2.30	0.922
Lymphonodi cervicale
No	105	Reference			Reference
Yes	36	72.29	17.02–307.07	< 0.001	36.7	7.68–175.35	< 0.001

HR hazard ratio, CI confidence interval; P^*: uni-variate regression analysis; P^#: multi-variate regression analysis. Note: entries in boldface means: P < 0.05

ISSN: 1471-2407