Table 3 Time interval from first recorded episode for specific inflammatory disease groups and odds of prostate cancer diagnosis
Time from first hospital episode to diagnosis/inclusion date | <12 months | 12- < 36 months | ≥ 36 months | > 60 months | |
|---|---|---|---|---|---|
ORa (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | p-trendb | |
DISEASE GROUPS (reference: no recorded episode) | |||||
Any chronic inflammatory /autoimmune disease (excl. Prostatitis and T1DM) | 1.01 (0.90–1.14) | 1.09 (1.02–1.16) | 1.04 (0.98–1.11) | 1.10 (1.05–1.15) | 0.371 |
Chronic inflammatory/infectious diseases (excl. prostatitis) | 0.93 (0.80–1.07) | 1.11 (1.03–1.20) | 1.07 (1.03–1.12) | 1.10 (1.04–1.16) | 0.390 |
Chronic Prostatitis | 3.93 (2.15–7.19) | 2.29 (1.66–3.16) | 1.52 (1.23–1.89) | 1.53 (1.15–2.03) | 0.004 |
Allergies (including asthma) | 1.25 (1.00–1.56) | 1.01 (0.88–1.15) | 1.04 (0.91–1.19) | 1.19 (1.05–1.28) | 0.480 |
Asthma alone | 1.63 (1.14–2.31) | 0.94 (0.74–1.18) | 0.99 (0.79–1.23) | 1.21 (1.05–1.40) | 0.700 |
Auto-immune diseases (excluding T1DM) | 1.05 (0.84–1.32) | 0.96 (0.85–1.09) | 1.03 (0.91–1.16) | 1.05 (0.97–1.13) | 0.425 |
Antibody negative | 1.13 (0.87–1.46) | 0.98 (0.85–1.13) | 1.12 (0.98–1.28) | 1.03 (0.94–1.14) | 0.981 |
Antibody positive - systemic | 0.92 (0.53–1.59) | 1.01 (0.76–1.34)) | 0.99 (0.74–1.33) | 1.13 (0.96–1.33) | 0.303 |
Antibody positive - organ confined (excl. T1DM) | 0.90 (0.47–1.69) | 1.01 (0.74–1.37) | 0.70 (0.48–1.03) | 1.06 (0.87–1.27) | 0.474 |
T1DM only | 0.97 (0.68–1.40) | 0.66 (0.53–0.81) | 0.71 (0.64–0.79) | 0.71 (0.63–0.81) | 0.673 |