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Table 2 Prior history of chronic inflammatory disease (CID) and odds of prostate cancer, overall and by disease categorya

From: Chronic inflammatory diseases, anti-inflammatory medications and risk of prostate cancer: a population-based case-control study

Prior record of chronic inflammatory diseaseb

Controls n = 139,311

Cases n = 27,874

Overall PCa

Favourable risk PCa

Unfavourable risk PCa

No. (%)

No. (%)

OR c (95% CI)

OR c (95% CI)

OR c (95% CI)

Any chronic inflammatory /autoimmune disease (excl. Prostatitis and T1DM)

26,272 (19)

5460 (20)

1.08 (1.04–1.12)

1.13 (1.08–1.19)

1.02 (0.96–1.07)

Chronic inflammatory / infectious diseases (excl. Prostatitis)

17,027 (12)

3520 (13)

1.07 (1.03–1.12)

1.10 (1.04–1.16)

1.05 (0.99–1.11)

Chronic prostatitis

492 (0.4)

180 (0.7)

1.82 (1.53–2.16)

2.03 (1.63–2.52)

1.56 (1.18–2.07)

Allergies (including Asthma)

5064 (4)

1084 (4)

1.10 (1.03–1.18)

1.22 (1.12–1.33)

0.97 (0.87–1.07)

Asthma alone

2116 (2)

456 (2)

1.13 (1.02–1.25)

1.22 (1.07–1.41)

1.03 (0.88–1.20)

Autoimmune diseases (any excluding T1DM):

7692 (5)

1542 (6)

1.03 (0.97–1.09)

1.07 (0.99–1.15)

0.98 (0.90–1.07)

Autoantibody negative

5349 (4)

1103 (4)

1.05 (0.98–1.12)

1.08 (0.99–1.18)

1.00 (0.90–1.10)

Autoantibody positive - systemic

1464 (1)

296 (1)

1.07 (0.94–1.21)

1.07 (0.90–1.28)

1.06 (0.89 = 1.27)

Autoantibody positive - organ specific

5221 (4)

774 (3)

0.77 (0.71–0.83)

0.74 (0.67–0.83)

0.82 (0.73–0.91)

Autoantibody positive - organ specific (excl. T1DM)

1152 (1)

220 (1)

0.98 (0.84–1.12)

1.08 (0.89–1.31)

0.85 (0.68–1.06)

T1DM

4136 (3)

506 (2)

0.71 (0.65–0.78)

0.64 (0.56–0.73)

0.80 (0.71–0.91)

  1. Aberrations: CI confidence interval, OR Odds Ratio, PCa prostate cancer, T1DM Type 1 diabetes mellitus
  2. aFavourable risk PCa: low and intermediate risk (Gleason Score ≤ 7, T1-T2, PSA ≤ 20 ng/mL, N0/X, & M0/X), Unfavourable risk PCa: (Gleason score 8–10, or PSA > 20 ng/ml, or N1, or M1)
  3. bDerived from ICD-10 diagnosis codes recorded in hospital admission or outpatient records since 1997. Reference category = no record of inpatient or outpatient hospital episode
  4. cAdjusted OR from conditional logistic regression with adjustment for civil status, education level and Charlson Comorbidity Index. Analyses stratified low/intermediate risk and advanced disease at diagnosis along with respective matched controls. Analysis undertaken on subset diagnosed 2007–09, with complete hospital admission data from Jan 1, 1997 – Dec 31, 2009
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BMC Cancer

ISSN: 1471-2407

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