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Table 1 Accumulation of PSMA tracers in different tissues

From: Peripheral ganglia in healthy rats as target structures for the evaluation of PSMA imaging agents

  n SCG, SUVBW SNR Liver, SUVBW Bone, SUVBW
[18F]DCFPyL 6 20.2 ± 5.8 6.7 ± 2.6 65.3 ± 21.7 12.4 ± 4.3
[18F]DCFPyL + 2-PMPA 3 4.6 ± 1.8* 3.7 ± 2.1 47.0 ± 7.7 6.1 ± 1.9
[Al18F]PSMA-11 3 36.8 ± 9.5* 4.5 ± 1.4 15.5 ± 4.2* 122.8 ± 50.1*
[68Ga]PSMA-11 3 41.0 ± 3.4* 4.5 ± 0.1 47.0 ± 10.4 18.5 ± 0.61
ANOVA main effect   F (3, 11)=24.8 p < 0.0001 F (3, 11) =1.7 p = 0.2167 F (3, 11) = 6.7 p = 0.0079 F (3, 11) = 21.1 p < 0.0001
  1. Abbreviations: SCG: superior cervical ganglion, SNR signal-to-noise ratio measured for SCG. *Significantly different from [18F]DCFPyL; p < 0.05 in Dunnett’s multiple comparison test