Possible predisposition for colorectal carcinogenesis due to altered gene expressions in normal appearing mucosa from patients with colorectal neoplasia

Table 2 Difference in mRNA expression in CRN versus controls

	Control mean (±SEM)	CRN mean (±SEM)	Fold change	P
PLA2G4A	0.0063 (± 0.0008)	0.0110 (± 0.0017)	1.75	0.020*
COX-1	0.0054 (± 0.0007)	0.0069 (± 0.0009)	1.26	0.252
COX-2	0.0022 (± 0.0006)	0.0029 (± 0.0007)	1.31	0.490
PTGES	0.0008 (± 0.0001)	0.0010 (± 0.0002)	1.26	0.388
EP1	0.000029 (± 0.0000079)	0.000034 (± 0.0000064)	1.18	0.626
EP2	0.0013 (± 0.0002)	0.0018 (± 0.0003)	1.33	0.207
EP3	0.0011 (± 0.0002)	0.0026 (± 0.0005)	2.34	0.016*
EP4	0.0217 (± 0.0021)	0.0305 (± 0.0047)	1.41	0.096
PGT	0.0301 (± 0.0032)	0.0364 (± 0.0038)	1.21	0.217
15-PGDH	0.2283 (± 0.0572)	0.4350 (± 0.0921)	1.91	0.066
ERK1	0.0640 (± 0.0076)	0.1198 (± 0.0171)	1.87	0.007**
ERK2	0.0018 (± 0.0002)	0.0036 (± 0.0007)	2.00	0.020*
Akt1	0.0311 (± 0.0033)	0.0564 (± 0.0092)	1.82	0.020*
Akt2	0.0193 (± 0.0020)	0.0283 (± 0.0035)	1.46	0.041*
β-Catenin	0.1694 (± 0.0197)	0.2662 (± 0.0486)	1.57	0.082
GSK3β	0.0289 (± 0.0031)	0.0759 (± 0.0220)	2.63	0.054
PPP2R1B	0.0196 (± 0.0022)	0.0317 (± 0.0048)	1.62	0.030*
PTPRM	0.0079 (± 0.0011)	0.0142 (± 0.0029)	1.81	0.059

Control group: N = 13, CRN group: N = 14. Data are expressed as the mean (±SEM) and as fold change of mRNA expression in CRN group compared to control group. * = p < 0.05, ** = p < 0.01

ISSN: 1471-2407