Fig. 6

Immunohistochemistry staining for YAP, KI-67 and Bcl-2 protein in xenograft tumour model and pulmonary metastasis model. Cytoplasmic staining was considered to be positive for YAP, KI-67 and Bcl-2. b&f Higher YAP expression in both xenograft tumour and pulmonary models. c&d High YAP expression mainly in the nucleus of LSCC. e&f Low YAP expression in LSCC in both the cytoplasm and nucleus of tumour cells. g&h Low expression of YAP protein mainly in the nucleus of LSCC. [A, a, E, e] × 40; [B, b, C, c, D, d, F, f, G, g, H, h] × 100