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Fig. 5 | BMC Cancer

Fig. 5

From: Knockdown of YAP inhibits growth in Hep-2 laryngeal cancer cells via epithelial-mesenchymal transition and the Wnt/β-catenin pathway

Fig. 5

a Targeted silencing of YAP suppresses laryngeal cancer tumourigenicity and metastasis in vivo. The effects of silenced YAP on tumour suppression in vivo. Images of tumours (left panel) formed in nude mice injected subcutaneously with Hep-2 cells transfected with control, negative vector, and YAP-shRNA. Fluorescence images (right panel) of tumours captured on the IVIS system 21 days after subcutaneous injection. Cells of each group were stably transfected with luciferase. Tumours with YAP knockdown were smaller compared to the other groups. Tumour growth curves are plotted. **P < 0.01. b A pulmonary metastasis model (left panel) was established after 3 weeks of the indicated treatment. Images from the pulmonary metastasis model and the corresponding statistical analysis are shown. **P < 0.01

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