Table 2 Difference in clinicopathological features due to calcium channel blockersa
Parameters | All case (n = 338) | TNBC (n = 105) | HER2BC (n = 78) | ||||||
|---|---|---|---|---|---|---|---|---|---|
Calcium channel blockers | p value | Calcium channel blockers | p value | Calcium channel blockers | p value | ||||
No (n = 297) | Yes (n = 41) | No (n = 94) | Yes (n = 11) | No (n = 68) | Yes (n = 10) | ||||
Age (years old) | |||||||||
 ≤ 55 | 170 (57.2%) | 7 (17.1%) | < 0.001 | 59 (62.8%) | 2 (18.2%) | 0.004 | 27 (39.7%) | 2 (20.0%) | 0.234 |
 > 55 | 127 (42.8%) | 34 (82.9%) | 35 (37.2%) | 9 (81.8%) | 41 (60.3%) | 8 (80.0%) | |||
Tumor size (mm) | |||||||||
 ≤ 50 | 258 (86.9%) | 36 (87.8%) | 0.868 | 82 (87.2%) | 8 (72.7%) | 0.197 | 60 (88.2%) | 10 (100.0%) | 0.258 |
 > 50 | 39 (13.1%) | 5 (12.2%) | 12 (12.8%) | 3 (27.3%) | 8 (11.8%) | 0 (0.0%) | |||
Skin infiltration | |||||||||
 Negative | 255 (85.9%) | 33 (80.5%) | 0.365 | 86 (91.5%) | 8 (72.7%) | 0.055 | 58 (85.3%) | 9 (90.0%) | 0.694 |
 Positive | 42 (14.1%) | 8 (19.5%) | 8 (8.5%) | 3 (27.3%) | 10 (14.7%) | 1 (10.0%) | |||
Lymph node status | |||||||||
 Negative | 102 (34.3%) | 12 (29.3%) | 0.887 | 28 (29.8%) | 4 (36.4%) | 0.658 | 28 (41.2%) | 4 (40.0%) | 0.945 |
 Positive | 195 (65.7%) | 29 (70.7%) | 66 (70.2%) | 7 (63.6%) | 40 (58.8%) | 6 (60.0%) | |||
Estrogen receptor | |||||||||
 Negative | 166 (55.9%) | 21 (51.2%) |  | – | – | – | – | – | – |
 Positive | 131 (44.1%) | 20 (48.8%) | 0.574 | – | – | – | – | ||
Progesterone receptor | |||||||||
 Negative | 207 (69.7%) | 29 (70.7%) | 0.893 | – | – | – | – | – | – |
 Positive | 90 (30.3%) | 12 (29.3%) | – | – | – | – | |||
HER2 | |||||||||
 Negative | 190 (64.0%) | 24 (58.5%) | 0.500 | – | – |  | – | – | – |
 Positive | 107 (36.0%) | 17 (41.5%) | – | – | – | – | |||
Ki67 | |||||||||
 ≤ 15% | 87 (29.3%) | 18 (43.9%) | 0.058 | 16 (17.0%) | 2 (18.2%) | 0.924 | 15 (22.1%) | 5 (50.0%) | 0.060 |
 > 15% | 210 (70.7%) | 23 (56.1%) | 78 (83.0%) | 9 (81.8%) | 53 (77.9%) | 5 (50.0%) | |||
Intrinsic subtype Luminal BC | |||||||||
 HER2BC, TNBC | 162 (54.5%) | 21 51.2%) | 0.690 | – | – |  | – | – | – |
 Luminal BC | 135 (45.5%) | 20 (48.8%) | – | – | – | – | |||
Intrinsic subtype HER2BC | |||||||||
 Luminal BC, TNBC | 229 (77.1%) | 31 (75.6%) | 0.832 | – | – |  | – | – | – |
 HER2BC | 68 (22.9%) | 10 (24.4%) | – | – | – | – | |||
Intrinsic subtype TNBC | |||||||||
 Luminal BC, HER2BC | 203 (68.4%) | 30 (73.2%) | 0.5332 | – | – |  | – | – | – |
 TNBC | 94 (31.6%) | 11 (26.8%) | – | – | – | – | |||
Objective response rate | |||||||||
 Non-Responders | 32 (10.8%) | 8 (19.5%) | 0.105 | 12 (12.8%) | 4 (36.4%) | 0.040 | 5 (7.4%) | 0 (0.0%) | 0.382 |
 Responders | 265 (89.2%) | 33 (80.5%) | 82 (87.2%) | 7 (63.6%) | 63 (92.6%) | 10 (100.0%) | |||
Pathological response | |||||||||
 Non-pCR | 195 (65.7%) | 27 (65.9%) | 0.980 | 53 (56.4%) | 7 (63.6%) | 0.649 | 33 (48.5%) | 2 (20.0%) | 0.093 |
 pCR | 102 (34.3%) | 14 (34.1%) | 41 (43.6%) | 4 (36.4%) | 35 (51.5%) | 8 (80.0%) | |||
TILs | |||||||||
 Low | 152 (51.2%) | 28 (68.3%) | 0.040 | 38 (40.4%) | 9 (81.8%) | 0.009 | 22 (32.4%) | 3 (30.0%) | 0.884 |
 High | 145 (48.8%) | 13 (31.7%) | 56 (59.6%) | 2 (18.2%) | 46 (67.6%) | 7 (70.0%) | |||
Hypertension | |||||||||
 No | 273 (91.9%) | 0 (0.0%) | < 0.001 | 90 (95.7%) | 0 (0.0%) | < 0.001 | 60 (88.2%) | 0 (0.0%) | < 0.001 |
 Yes | 24 (8.1%) | 41 (100.0%) | 4 (4.3%) | 11 (100.0%) | 8 (11.8%) | 10 (100.0%) | |||
Multiple types of AHT | |||||||||
 No | 293 (98.6%) | 21 (51.2%) | < 0.001 | 93 (98.9%) | 6 (54.5%) | < 0.001 | 67 (98.5%) | 4 (40.0%) | < 0.001 |
 Yes | 4 (1.4%) | 20 (48.8%) | 1 (1.1%) | 5 (45.5%) | 1 (1.5%) | 6 (60.0%) | |||
ACEi or ARBs | |||||||||
 No | 281 (94.6%) | 24 (58.5%) | < 0.001 | 91 (96.8%) | 8 (72.7%) | 0.001 | 62 (91.2%) | 4 (40.0%) | < 0.001 |
 Yes | 16 (5.4%) | 17 (41.5%) | 3 (3.2%) | 3 (27.3%) | 6 (8.8%) | 6 (60.0%) | |||
Beta-blockers | |||||||||
 No | 289 (97.3%) | 37 (90.2%) | 0.022 | 93 (98.9%) | 3 (27.3%) | < 0.001 | 66 (97.1%) | 10 (100.0%) | 0.589 |
 Yes | 8 (2.7%) | 4 (9.8%) | 1 (1.1%) | 8 (72.7%) | 2 (2.9%) | 0 (0.0%) | |||
Diuretics | |||||||||
 No | 293 (98.6%) | 38 (92.7%) | 0.012 | 93 (98.9%) | 10 (90.9%) | 0.066 | 67 (98.5%) | 10 (100.0%) | 0.704 |
 Yes | 4 (1.4%) | 3 (7.3%) | 1 (1.1%) | 1 (9.1%) | 1 (1.5%) | 0 (0.0%) | |||