Table 2 Top rank predictive clinicopathological variables in the ANN models for each of the axillary nodal status outcome
From: Artificial neural network models to predict nodal status in clinically node-negative breast cancer
Predictors | Ranka | ORb |
|---|---|---|
N0 vs. N+ (n = 800) | ||
Tumor size, per mm | 100.00 | 0.950 (0.917–0.984) |
Vascular invasion, present vs. absent | 40.94 | 0.409 (0.201–0.681) |
Multifocality, present vs. absent | 14.61 | 0.670 (0.452–0.910) |
ER status, positive vs. negative | 10.49 | 0.618 (0.312–1.110) |
Histological type | 9.98 | |
Ductal | 1 [reference] | |
Lobular | 1.092 (0.692–1.688) | |
Other | 2.033 (1.112–3.751) | |
PR status, positive vs. negative | 9.60 | 0.678 (0.443–0.962) |
Mode of detection, mammographic screening vs. symptomatic presentation | 7.97 | 1.310 (0.987–1.705) |
Age, per year | 6.76 | 1.010 (0.997–1.024) |
Tumor localization in the breastc | 6.47 | |
Upper outer quadrant | 1 [reference] | |
Central | 1.137 (0.592–2.099) | |
Upper inner quadrant | 1.323 (0.922–1.889) | |
Lower inner quadrant | 1.112 (0.500–2.034) | |
Lower outer quadrant | 0.680 (0.383–1.039) | |
Ki67, percentage | 5.07 | 0.996 (0.981–1.009) |
N1 vs. N0 (n = 746) | ||
Tumor size, per mm | 100.0 | 1.050 (1.016–1.087) |
Vascular invasion, present vs. absent | 46.15 | 2.492 (1.440–4.376) |
Multifocality, present vs. absent | 16.47 | 1.527 (1.101–2.180) |
PR status, positive vs. negative | 14.36 | 1.613 (1.058–2.409) |
Histological type | 10.55 | |
Ductal | 1 [reference] | |
Lobular | 0.785 (0.466–1.131) | |
Other | 0.491 (0.242–0.872) | |
ER status, positive vs. negative | 9.04 | 1.657 (0.813–2.895) |
Age, per year | 6.95 | 0.992 (0.978–1.003) |
Tumor localization in the breastc | 6.03 | |
Upper outer quadrant | 1 [reference] | |
Central | 0.805 (0.324–1.415) | |
Upper inner quadrant | 0.741 (0.510–1.080) | |
Lower inner quadrant | 0.974 (0.476–1.759) | |
Lower outer quadrant | 1.462 (0.915–2.369) | |
Ki67, percentage | 5.07 | 1.002 (0.992–1.014) |
Menopausal status, postmenopause vs. premenopause | 4.88 | 0.783 (0.504–1.065) |
N2 vs. N0 and N1 (n = 800) | ||
Tumor size, per mm | 100.0 | 1.039 (1.020–1.054) |
Vascular invasion, present vs. absent | 36.71 | 1.805 (1.345–2.451) |
ER status, positive vs. negative | 13.25 | 1.777 (1.357–2.873) |
Histological type | 4.55 | |
Ductal | 1 [reference] | |
Lobular | 1.658 (1.252–2.083) | |
Other | 0.910 (0.401–1.194) | |
Tumor localization in the breastc | 3.48 | |
Upper outer quadrant | 1 [reference] | |
Central | 1.208 (0.739–2.033) | |
Upper inner quadrant | 1.012 (0.778–1.270) | |
Lower inner quadrant | 1.077 (0.684–1.410) | |
Lower outer quadrant | 1.544 (1.134–2.021) | |
Multifocality, present vs. absent | 2.32 | 1.219 (1.033–1.338) |