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Table 2 Univariate and multivariate analyses (Cox regression) for overall survival in MDS patients

From: Long non-coding RNA HOXB-AS3 promotes myeloid cell proliferation and its higher expression is an adverse prognostic marker in patients with acute myeloid leukemia and myelodysplastic syndrome

Variables

Univariate analysis

Multivariate analysis

HR

95% CI

P value

HR

95% CI

P value

Age > 60 years

1.7988

1.1298 to 2.8641

0.0223*

1.5433

0.8392 to 2.8383

0.1628

IPSS

3.4616

1.9730 to 6.0735

< 0.0001*

2.5755

1.4292 to 4.6412

0.0016*

EZH2 mutation

2.0164

0.7036 to 5.7785

0.0709

1.1877

0.4371 to 3.2271

0.7358

RUNX1 mutation

1.6949

0.7996 to 3.5925

0.0880

0.7265

0.3155 to 1.6731

0.4528

ASXL1 mutation

1.9909

1.0927 to 3.6274

0.0059*

1.3616

0.6273 to 2.9554

0.4350

IDH2 mutation

1.5777

0.2748 to 9.0568

0.5195

–

–

–

ZRSR2 mutation

2.5929

1.0588 to 6.3500

0.0016*

1.9474

0.8973 to 4.2263

0.0918

U2AF35 mutation

1.0584

0.4771 to 2.3480

0.8861

–

–

–

TET2 mutation

1.3481

0.6591 to 2.7572

0.3579

–

–

–

SRSF2 mutation

1.9654

0.9379 to 4.1184

0.0196*

1.5304

0.7107 to 3.2954

0.2769

SF3B1 mutation

0.7602

0.4237 to 1.3640

0.3970

–

–

–

TP53 mutation

7.1283

1.2057 to 42.1423

< 0.001*

6.1091

2.3732 to 15.7260

0.0002*

DNMT3A mutation

1.2781

0.6513 to 2.5080

0.4344

–

–

–

HOXB-AS3 expression

2.1624

1.1681 to 4.0033

0.0018*

1.8992

1.0606 to 3.4009

0.0309*

  1. Age, elder than 60 years versus younger; HOXB-AS3 expression, highest versus others; mutations, mutation versus wild type; IPSS, intermediate-2 and high, versus low and intermediate-1
  2. Abbreviations: HR hazard ratio, CI confidence interval
  3. * P value < 0.05
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BMC Cancer

ISSN: 1471-2407

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