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Fig. 4 | BMC Cancer

Fig. 4

From: CDCA2 promotes the proliferation of colorectal cancer cells by activating the AKT/CCND1 pathway in vitro and in vivo

Fig. 4

CDCA2 influences the G1/S phase transition of the cell cycle through regulating CCND1 expression. a GSEA plot showing that CDCA2 expression positively correlated with cell-cycle-activated gene signatures, especially in G1-S phase transition (GO_CELL_CYCLE_PHASE_TRANSITION, GO_CELL_CYCLE_G1 _S_PHASE_TRANSITION). b and c CDCA2 promoted the G1/S transition in CRC cell lines. d qRT-PCR was conducted to determine the key regulators of the G1-S phase transition. e Key regulators of the G1 phase were evaluated by western blotting to clarify the specific role of CDCA2 in the G1/S phase transition

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