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Table 2 Mutation patterns in 84 patients with mutant EGFR stratified based on TTF-1 status

From: Thyroid transcription factor-1 as a prognostic indicator for stage IV lung adenocarcinoma with and without EGFR-sensitizing mutations

EGFR mutations

TTF-1 positive (n = 79)

n (%)

TTF-1 negative (n = 5)

n (%)

Total

(n = 84)

n (%)

P value

Exon 18 G719X

8 (10.1)

1 (20.0)

9 (10.7)

0.441

Exon 19 deletion

43 (54.4)

1 (20.0)

44 (52.4)

0.187

Exon 21 L858R

30 (38.0)

3 (60.0)

33 (39.3)

0.377

de novo T790 M

1 (1.3)

0 (0)

1 (1.2) a

1.000

Acquired T790 M

15/27 (55.6)

0 (0)

15/27 (55.6)

NA

  1. Abbreviations: EGFR epidermal growth factor receptor, TTF-1 thyroid transcription factor 1
  2. aOne patient initially had triple EGFR mutations, which included deletion in exon 19, G719X, and de novo T790 M
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BMC Cancer

ISSN: 1471-2407

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