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Table 1 Analysis results for incident breast cancer in EstBB using different GRSs and metaGRSs

From: Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification

Score

NCI

GRS70

GRS75

GRSUK

GRSONCO

metaGRS4

metaGRS3

metaGRS2

HRa per 1 SD with 95% CI

1.7

1.52–1.9

1.44

1.29–1.61

1.59

1.42–1.78

1.23

1.1–1.38

1.52

1.35–1.7

1.61

1.43–1.80

1.65

1.47–1.85

1.65

1.48–1.86

p-value

1.4*10− 20

3.2*10− 10

1.1*10− 15

4*10− 4

1.7*10− 12

4.4*10− 16

1.43*10− 17

7.6*10−18

Harrell’ s c –statistic

0.677

0.603

0.627

0.561

0.615

0.634

0.637

0.636

Harrell’ s c –statistic NCI + GRS

NA

0.701 (∆ = 0.024)

0.708 (∆ = 0.031)

0.684 (∆ = 0.007)

0.705 (∆ = 0.028)

0.715 (∆ = 0.038)

0.716 (∆ = 0.039)

0.715 (∆ = 0.038)

  1. Legend: Harrell’s c-statistics for all versions of genetic risk scores and National Cancer Institute Breast Cancer Assessment Tool risk estimates (based on age, race, age at menarche and age at first live birth) were calculated. ∆-GRS added improvement in c-statistics compared to NCI alone. * Hazard ratio for developing breast cancer is given per 1 SD increase. CI = confidence intervals; GRS = genetic risk score; HR = Hazard ratio; NCI – National Cancer Institute Breast Cancer assessment tool estimates calculated with R package BCRA
  2. No evidence of the interactions between any GRSs and NCI estimates were found (p-values > 0.16)
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BMC Cancer

ISSN: 1471-2407

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