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Fig. 2 | BMC Cancer

Fig. 2

From: LncRNA WWC2-AS1 functions AS a novel competing endogenous RNA in the regulation of FGF2 expression by sponging miR-16 in radiation-induced intestinal fibrosis

Fig. 2

FGF2 expression pattern and CNC network in RIF and non-RIF tissues. a RT-qPCR analysis of FGF2 mRNA expression between the RIF and non-RIF tissue samples. b Western blotting analysis of FGF2 expression. c FGF2-associated lncRNA network was performed by GO analysis. The blue node represents the FGF2 mRNA, the red nodes represent lncRNA related with FGF2. ENST00000511846 represents lncRNA-WWC2-AS1. Lines represent positive correlation and dotted lines represent negative correlation. dThe TargetScan, miRanda, and miRBase databases were used to predict the interactions of FGF2, miRNAs, and lncRNAs and build the lncRNA-miRNA-FGF2 network diagram. The green node represents the FGF2 mRNA, the blue nodes represent different lncRNAs, and the red nodes represent different miRNAs. The lines between the lncRNAs, miRNAs, and FGF2 represent direct interactions between lncRNAs and miRNAs, with FGF2 as the target of the miRNAs. e RT-qPCR analysis of FGF2 mRNA, WWC2-AS1 and miR-16 expression in the RIF and non-RIF tissues samples. The data are expressed as the mean ± SEM, *P < 0.05, **P < 0.01, compared to non-RIF tissues

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BMC Cancer

ISSN: 1471-2407

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