Fig. 1

H2A.X^Y142ph was down-regulated by Ras-ERK1/2 pathway. SNU-16 cells and MKN1 cells were transfected with empty-pEGFP-N1 (pEGFP-N1), pEGFP-K-Ras^WT (Ras^WT), pEGFP-K-Ras^G12V/T35S (Ras^G12V/T35S) plasmids. a The H2A.X ^Y142ph levels and (b) the phosphorylation of ERK1/2 were measured using western blot in SNU-16 cells. c The H2A.X ^Y142ph levels and (d) the phosphorylation of ERK1/2 were measured using western blot in MKN1 cells. Data presented as mean + SD, ** P < 0.01 (n = 3)